Proteinase-Activated Receptor 1 (F2R) Antibody – Mouse Polyclonal

PAR1: a G-protein coupled high-affinity receptor for activated thrombin or trypsin. Coupled to G proteins that stimulate phosphoinositide hydrolysis. Coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelet activation and in vascular development.

Protein type: GPCR, family 1; Membrane protein, integral; Cell development/differentiation; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: Golgi apparatus; postsynaptic membrane; integral to plasma membrane; early endosome; extracellular region; plasma membrane; caveola; neuromuscular junction

Molecular Function: G-protein coupled receptor activity; protein binding; G-protein beta-subunit binding; G-protein alpha-subunit binding; thrombin receptor activity; receptor binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of blood coagulation; activation of MAPKK activity; negative regulation of glomerular filtration; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; positive regulation of caspase activity; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; connective tissue replacement during inflammatory response; platelet dense granule organization and biogenesis; positive regulation of MAPKKK cascade; regulation of interleukin-1 beta production; positive regulation of cell proliferation; protein kinase C activation; response to wounding; positive regulation of smooth muscle contraction; negative regulation of neuron apoptosis; inflammatory response; establishment of synaptic specificity at neuromuscular junction; STAT protein nuclear translocation; caspase activation; platelet activation; anatomical structure morphogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of Rho protein signal transduction; positive regulation of phosphoinositide 3-kinase cascade; tyrosine phosphorylation of STAT protein; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells within a tissue; release of sequestered calcium ion into cytosol; regulation of blood coagulation; positive regulation of vasoconstriction; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of calcium ion transport; blood coagulation; positive regulation of cell migration