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PTPN21 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630244

PTPD1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains… More details

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Product Overview

Online Datasheet in PDF
Product Name
PTPD1 (PTPN21), Polyclonal Antibody
Full Product Name
PTPD1, ID (Tyrosine-protein Phosphatase Non-receptor Type 21, Protein-tyrosine Phosphatase D1, PTPN21)
Product Gene Name
anti-PTPN21 antibody
Product Synonym Names
Anti -PTPD1, ID (Tyrosine-protein Phosphatase Non-receptor Type 21, Protein-tyrosine Phosphatase D1, PTPN21)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PTPD1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
133,281 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (88932122..89021123, complement). Location: 14q31.3
OMIM
603271
3D Structure
ModBase 3D Structure for Q16825
Immunogen
Synthetic peptide selected from the center region of human PTPD1 (KLH).

Product Categories/Family for anti-PTPN21 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-PTPN21 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTPN21 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-PTPN21 antibody

Western Blot analysis in placenta tissue lysate (35ug/lane) using MBS630244. PTPD1(arrow) was detected using MBS630244.
Rabbit Anti-PTPN21 Polyclonal Antibody – Cat# MBS630244

Western Blot (WB) of anti-PTPN21 antibody

Western Blot analysis in Jurkat whole cell lysate (20ug) using MBS630244 (1:1000). Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 133kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-PTPN21 Polyclonal Antibody, Western Blot (WB) – Cat# MBS630244

Other Notes

Small volumes of anti-PTPN21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN21 purchase

MBS630244 is an antibody targeting PTPN21. Also known as PTPD1, ID (Tyrosine-protein Phosphatase Non-receptor Type 21, Protein-tyrosine Phosphatase D1, PTPN21). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN21. It may not necessarily be applicable to this product.

NCBI GI #
530403001
NCBI GeneID
11099
NCBI Accession #
XP_005267344.1
UniProt Primary Accession #
Q16825
UniProt Related Accession #
Q16825
GenBank Nucleotide #
XM_005267287.1
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 21 isoform X1
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 21
NCBI Official Symbol
PTPN21
NCBI Official Synonym Symbols
PTPD1; PTPRL10
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 21
UniProt Synonym Protein Names
Protein-tyrosine phosphatase D1
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN21
UniProt Synonym Gene Names
PTPD1
UniProt Entry Name
PTN21_HUMAN
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 21; protein tyrosine phosphatase D1; protein-tyrosine phosphatase D1; dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)

NCBI Summary for PTPN21

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for PTPN21

PTPN21: is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q31.3

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding; protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation
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Research Articles on PTPN21

1. The results that 2 non-synonymous markers in PTPN21 are associated with schizophrenia, further investigation of this locus is warranted.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN21 antibody

 Reference Product  PubMed Publications
 SRC antibody  >4 publications with PTPN21 and SRC
 AKAP1 antibody  >2 publications with PTPN21 and AKAP1
 TEC antibody  >1 publications with PTPN21 and TEC
 BMX antibody  >1 publications with PTPN21 and BMX

Pathways associated with anti-PTPN21 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies  Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram

Diseases associated with anti-PTPN21 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with PTPN21 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with PTPN21 and Cell Transformation, Neoplastic
 Urinary Bladder Neoplasms Antibodies  >1 publications with PTPN21 and Urinary Bladder Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with PTPN21 and Neoplasm Metastasis

Organs/Tissues associated with anti-PTPN21 antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >1 publications with PTPN21 and Connective Tissue
 Kidney Antibodies  >1 publications with PTPN21 and Kidney
 Skin Antibodies  >1 publications with PTPN21 and Skin
 Bone Antibodies  >1 publications with PTPN21 and Bone
 Placenta Antibodies  >1 publications with PTPN21 and Placenta
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