Rabbit Anti-GNMT Polyclonal Antibody – Cat# MBS6303109

Western blot analysis of GNMT (arrow) using rabbit polyclonal GNMT Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GNMT gene.

GNMT Antibody – Rabbit Polyclonal

Name: GNMT Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6303109
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6303109

The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNMT, Polyclonal Antibody

Full Product Name

GNMT, ID (GNMT, Glycine N-methyltransferase) (FITC)

Product Gene Name

anti-GNMT antibody

Product Synonym Names

GNMT; Glycine N-methyltransferase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

32,742 Da

OMIM

gene 606664

3D Structure

ModBase 3D Structure for Q14749

Immunogen

GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human GNMT.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-GNMT antibody

Antibodies; Enzymes; Methyltransferase

Applications Tested/Suitable for anti-GNMT antibody

Western Blot (WB), FLISA

Application Notes for anti-GNMT antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GNMT antibody

Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010): Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009): Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009). Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009). Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009).

Other Notes

Small volumes of anti-GNMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNMT purchase

MBS6303109 is an antibody targeting GNMT. Also known as GNMT, ID (GNMT, Glycine N-methyltransferase) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GNMT. It may not necessarily be applicable to this product.

NCBI GI #

9506741

NCBI GeneID

27232

NCBI Accession #

NP_061833.1

UniProt Primary Accession #

Q14749

UniProt Secondary Accession #

Q5T8W2; Q9NNZ1; Q9NS24

UniProt Related Accession #

Q14749

GenBank Nucleotide #

NM_018960.4

NCBI Official Full Name

glycine N-methyltransferase

NCBI Official Synonym Full Names

glycine N-methyltransferase

NCBI Official Symbol

GNMT

UniProt Protein Name

Glycine N-methyltransferase

Protein Family

Glycine N-methyltransferase

UniProt Gene Name

GNMT

UniProt Entry Name

GNMT_HUMAN

NCBI Protein Information

glycine N-methyltransferase; HEL-S-182mP; epididymis secretory sperm binding protein Li 182mP

UniProt Comments for GNMT

GNMT: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Defects in GNMT are the cause of glycine N- methyltransferase deficiency (GNMT deficiency); also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase; EC 2.1.1.20

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: cytoplasm

Molecular Function: protein binding; glycine N-methyltransferase activity; glycine binding; folic acid binding

Biological Process: methylation; glycogen metabolic process; S-adenosylmethionine metabolic process; protein modification process; regulation of gluconeogenesis; methionine metabolic process; one-carbon compound metabolic process; protein homotetramerization

Disease: Glycine N-methyltransferase Deficiency

Research Articles on GNMT

1. GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GNMT antibody

Products by Pathway	Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-GNMT antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>47 publications with GNMT and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>39 publications with GNMT and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>28 publications with GNMT and Liver Neoplasms
Adenocarcinoma Antibodies	>25 publications with GNMT and Adenocarcinoma
Disease Models, Animal Antibodies	>21 publications with GNMT and Disease Models, Animal
Fatty Liver Antibodies	>13 publications with GNMT and Fatty Liver
Hepatitis Antibodies	>11 publications with GNMT and Hepatitis
Hepatitis, Chronic Antibodies	>8 publications with GNMT and Hepatitis, Chronic
Liver Cirrhosis Antibodies	>8 publications with GNMT and Liver Cirrhosis
Neoplasms, Experimental Antibodies	>8 publications with GNMT and Neoplasms, Experimental

Organs/Tissues associated with anti-GNMT antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>113 publications with GNMT and Liver
Blood Antibodies	>25 publications with GNMT and Blood
Prostate Antibodies	>9 publications with GNMT and Prostate
Kidney Antibodies	>7 publications with GNMT and Kidney
Pancreas Antibodies	>5 publications with GNMT and Pancreas
Lung Antibodies	>3 publications with GNMT and Lung