LRRK1 Antibody – Rabbit Polyclonal

LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; TKL group; LRRK family

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: mitochondrion; cytoplasm

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; GTP binding; metal ion binding; ATP binding

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; small GTPase mediated signal transduction; protein amino acid phosphorylation; bone resorption