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HMGCS1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630361

HMGCS1 condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HMGCS1, Polyclonal Antibody
Full Product Name
HMGCS1, CT (3-hydroxy-3-methylglutaryl Coenzyme A Synthase, Hydroxymethylglutaryl-CoA Synthase Cytoplasmic, HMG-CoA Synthase, HMGCS, MGC90332)
Product Gene Name
anti-HMGCS1 antibody
Product Synonym Names
Anti -HMGCS1, CT (3-hydroxy-3-methylglutaryl Coenzyme A Synthase, Hydroxymethylglutaryl-CoA Synthase Cytoplasmic, HMG-CoA Synthase, HMGCS, MGC90332)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human HMGCS1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,294 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (43287572..43313614, complement). Location: 5p14-p13
OMIM
142940
3D Structure
ModBase 3D Structure for Q01581
Immunogen
Synthetic peptide selected from the C-terminal region of human HMGCS1 (KLH).

Product Categories/Family for anti-HMGCS1 antibody

Antibodies; Abs to CoEnzyme A
Applications Tested/Suitable for anti-HMGCS1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-HMGCS1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-HMGCS1 antibody

Western blot analysis of HMGCS1 antibody (C-term) in K562 cell line lysates (35ug/lane). NKRF (arrow) was detected using the purified Pab.
Rabbit Anti-HMGCS1 Polyclonal Antibody – Cat# MBS630361

Immunohistochemistry (IHC) of anti-HMGCS1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with HMGCS1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-HMGCS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630361

Flow Cytometry (FC/FACS) of anti-HMGCS1 antibody

Flow cytometric analysis of hela cells using HMGCS1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HMGCS1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630361

Other Notes

Small volumes of anti-HMGCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HMGCS1 purchase

MBS630361 is an antibody targeting HMGCS1. Also known as HMGCS1, CT (3-hydroxy-3-methylglutaryl Coenzyme A Synthase, Hydroxymethylglutaryl-CoA Synthase Cytoplasmic, HMG-CoA Synthase, HMGCS, MGC90332). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HMGCS1. It may not necessarily be applicable to this product.

NCBI GI #
148298764
NCBI GeneID
3157
NCBI Accession #
NP_002121.4
UniProt Primary Accession #
Q01581
UniProt Secondary Accession #
B2RDL8
UniProt Related Accession #
Q01581
GenBank Nucleotide #
NM_002130.7
NCBI Official Full Name
hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
NCBI Official Symbol
HMGCS1
NCBI Official Synonym Symbols
HMGCS
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Synonym Protein Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
Protein Family
Hydroxymethylglutaryl-CoA synthase
UniProt Gene Name
HMGCS1
UniProt Synonym Gene Names
HMGCS; HMG-CoA synthase
UniProt Entry Name
HMCS1_HUMAN
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

UniProt Comments for HMGCS1

HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.3.10; Transferase; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 5p14-p13

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein homodimerization activity; organic acid binding; hydroxymethylglutaryl-CoA synthase activity; drug binding; isomerase activity

Biological Process: response to purine; response to drug; isoprenoid biosynthetic process; male gonad development; cellular lipid metabolic process; liver development; cholesterol biosynthetic process; response to low light intensity; response to vitamin E; response to tellurium ion; response to lipoprotein stimulus; lipid metabolic process; brain development
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Research Articles on HMGCS1

1. The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HMGCS1 antibody

 Reference Product  PubMed Publications
 EHHADH antibody  >1 publications with HMGCS1 and EHHADH
 PPARA antibody  >1 publications with HMGCS1 and PPARA
 HMGCL antibody  >1 publications with HMGCS1 and HMGCL
 SREBF2 antibody  >1 publications with HMGCS1 and SREBF2
 ACAT2 antibody  >1 publications with HMGCS1 and ACAT2

Pathways associated with anti-HMGCS1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram

Diseases associated with anti-HMGCS1 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >3 publications with HMGCS1 and Liver Diseases
 Mental Disorders Antibodies  >3 publications with HMGCS1 and Mental Disorders
 Fatty Liver Antibodies  >3 publications with HMGCS1 and Fatty Liver
 Liver Neoplasms Antibodies  >2 publications with HMGCS1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with HMGCS1 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with HMGCS1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >2 publications with HMGCS1 and Nervous System Diseases
 Abnormalities, Drug-Induced Antibodies  >2 publications with HMGCS1 and Abnormalities, Drug-Induced
 Inflammation Antibodies  >2 publications with HMGCS1 and Inflammation
 Movement Disorders Antibodies  >1 publications with HMGCS1 and Movement Disorders

Organs/Tissues associated with anti-HMGCS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with HMGCS1 and Liver
 Blood Antibodies  >5 publications with HMGCS1 and Blood
 Brain Antibodies  >3 publications with HMGCS1 and Brain
 Connective Tissue Antibodies  >2 publications with HMGCS1 and Connective Tissue
 Muscle Antibodies  >1 publications with HMGCS1 and Muscle
 Kidney Antibodies  >1 publications with HMGCS1 and Kidney
 Skin Antibodies  >1 publications with HMGCS1 and Skin
 Vascular Antibodies  >1 publications with HMGCS1 and Vascular
 Testis Antibodies  >1 publications with HMGCS1 and Testis
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