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CDON Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630409

CDON and BOC (MIM 608708) are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CDON, Polyclonal Antibody
Full Product Name
CDON (Cell adhesion molecule-related /down-regulated by oncogenes, MGC111524, ORCAM)
Product Gene Name
anti-CDON antibody
Product Synonym Names
Anti -CDON (Cell adhesion molecule-related /down-regulated by oncogenes, MGC111524, ORCAM)
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by peptide affinity chromatography.
Specificity
Recognizes CDO. Species sequence homology: human, canine, bovine.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
139,147 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (125826713..125933187, complement). Location: 11q24.2
OMIM
608707
3D Structure
ModBase 3D Structure for Q4KMG0
Immunogen
Synthetic peptide corresponding to C-KNRQQNTIQKYDP, from the internal region of human CDO (NP_058648.4).

Product Categories/Family for anti-CDON antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-CDON antibody
ELISA (EL/EIA)
Application Notes for anti-CDON antibody
Suitable for use in ELISA.
Dilution: Peptide ELISA Titer: 1:32,000

Other Notes

Small volumes of anti-CDON antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDON purchase

MBS630409 is an antibody targeting CDON. Also known as CDON (Cell adhesion molecule-related /down-regulated by oncogenes, MGC111524, ORCAM). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CDON. It may not necessarily be applicable to this product.

NCBI GI #
343790941
NCBI GeneID
50937
NCBI Accession #
NP_001230526.1
UniProt Primary Accession #
Q4KMG0
UniProt Secondary Accession #
O14631
UniProt Related Accession #
Q4KMG0
GenBank Nucleotide #
NM_001243597.1
NCBI Official Full Name
cell adhesion molecule-related/down-regulated by oncogenes isoform 1
NCBI Official Synonym Full Names
cell adhesion associated, oncogene regulated
NCBI Official Symbol
CDON
NCBI Official Synonym Symbols
CDO; CDON1; HPE11; ORCAM
UniProt Protein Name
Cell adhesion molecule-related/down-regulated by oncogenes
Protein Family
Cell adhesion molecule-related/down-regulated by oncogenes
UniProt Gene Name
CDON
UniProt Synonym Gene Names
CDO
UniProt Entry Name
CDON_HUMAN
NCBI Protein Information
cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog; surface glycoprotein, Ig superfamily member

NCBI Summary for CDON

This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
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UniProt Comments for CDON

CDON: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Defects in CDON are the cause of holoprosencephaly type 11 (HPE11). HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: extracellular matrix; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: lens development in camera-type eye; regulation of protein heterodimerization activity; smoothened signaling pathway; satellite cell differentiation; cell fate specification; positive regulation of skeletal muscle development; positive regulation of small GTPase mediated signal transduction; anterior/posterior pattern formation; muscle cell differentiation; embryonic body morphogenesis; positive regulation of MAPKKK cascade; embryonic retina morphogenesis in camera-type eye; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; cerebral cortex development; positive regulation of neuron differentiation; cell adhesion; myoblast fusion

Disease: Holoprosencephaly 11
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Research Articles on CDON

1. Mutations in the CDON cause holoprosencephaly. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDON antibody

 Reference Product  PubMed Publications
 SHH antibody  >13 publications with CDON and SHH
 GAS1 antibody  >5 publications with CDON and GAS1
 IHH antibody  >2 publications with CDON and IHH
 SPAG9 antibody  >1 publications with CDON and SPAG9
 GLI2 antibody  >1 publications with CDON and GLI2
 DHH antibody  >1 publications with CDON and DHH

Pathways associated with anti-CDON antibody

 Products by Pathway  Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram

Diseases associated with anti-CDON antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >8 publications with CDON and Congenital Abnormalities
 Nervous System Diseases Antibodies  >7 publications with CDON and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >7 publications with CDON and Craniofacial Abnormalities
 Abnormalities, Multiple Antibodies  >7 publications with CDON and Abnormalities, Multiple
 Nervous System Malformations Antibodies  >6 publications with CDON and Nervous System Malformations
 Neoplasms Antibodies  >3 publications with CDON and Neoplasms
 Prostatic Diseases Antibodies  >2 publications with CDON and Prostatic Diseases
 Embryo Loss Antibodies  >2 publications with CDON and Embryo Loss
 Brain Diseases Antibodies  >1 publications with CDON and Brain Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with CDON and Abnormalities, Drug-Induced

Organs/Tissues associated with anti-CDON antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with CDON and Muscle
 Brain Antibodies  >4 publications with CDON and Brain
 Embryonic Tissue Antibodies  >4 publications with CDON and Embryonic Tissue
 Eye Antibodies  >2 publications with CDON and Eye
 Skin Antibodies  >1 publications with CDON and Skin
 Adipose Tissue Antibodies  >1 publications with CDON and Adipose Tissue
 Connective Tissue Antibodies  >1 publications with CDON and Connective Tissue
 Mouth Antibodies  >1 publications with CDON and Mouth
 Placenta Antibodies  >1 publications with CDON and Placenta
 Bone Antibodies  >1 publications with CDON and Bone
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