• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GRM7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6304521

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRM7, Polyclonal Antibody
Full Product Name
GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7) (MaxLight 550)
Product Gene Name
anti-GRM7 antibody
Product Synonym Names
GRM7; GPRC1G; MGLUR7; Metabotropic glutamate receptor 7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
102,251 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (6902802..7783218). Location: 3p26.1-p25.1
OMIM
604101
3D Structure
ModBase 3D Structure for Q14831
Immunogen
GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-269 amino acids from the N-terminal region of human GRM7.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-GRM7 antibody

Antibodies; G Protein Receptors
Applications Tested/Suitable for anti-GRM7 antibody
Western Blot (WB), FLISA
Application Notes for anti-GRM7 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GRM7 antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). Schulz, H.L., et al. Neurosci. Lett. 326(1):37-40(2002).

Other Notes

Small volumes of anti-GRM7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRM7 purchase

MBS6304521 is an antibody targeting GRM7. Also known as GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM7. It may not necessarily be applicable to this product.

NCBI GI #
4504147
NCBI GeneID
2917
NCBI Accession #
NP_000835.1
NCBI Related Accession #
NP_870989.1
UniProt Primary Accession #
Q14831
UniProt Secondary Accession #
Q8NFS2; Q8NFS3; Q8NFS4
UniProt Related Accession #
Q14831
GenBank Nucleotide #
NM_000844.3
NCBI Official Full Name
metabotropic glutamate receptor 7 isoform a
NCBI Official Synonym Full Names
glutamate receptor, metabotropic 7
NCBI Official Symbol
GRM7
NCBI Official Synonym Symbols
GLUR7; MGLU7; GPRC1G; MGLUR7
UniProt Protein Name
Metabotropic glutamate receptor 7
Protein Family
Metabotropic glutamate receptor
UniProt Gene Name
GRM7
UniProt Synonym Gene Names
GPRC1G; MGLUR7; mGluR7
UniProt Entry Name
GRM7_HUMAN
NCBI Protein Information
metabotropic glutamate receptor 7

UniProt Comments for GRM7

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: presynaptic membrane; asymmetric synapse; postsynaptic membrane; axon; integral to plasma membrane; dendrite; presynaptic active zone; integral to membrane; plasma membrane; dendritic shaft; cell cortex; receptor complex

Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding

Biological Process: behavioral fear response; regulation of synaptic transmission, glutamatergic; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway
Show more

Research Articles on GRM7

1. Mixed modeling analyses explored the relationship of GRM7 haplotype and SNP genotypes with measures of auditory perception. GRM7 alleles are associated primarily with peripheral measures of hearing loss, and with speech detection in older adults.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRM7 antibody

 Reference Product  PubMed Publications
 GRIP1 antibody  >1 publications with GRM7 and GRIP1

Pathways associated with anti-GRM7 antibody

 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-GRM7 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with GRM7 and Nervous System Diseases
 Attention Deficit Disorder with Hyperactivity Antibodies  >4 publications with GRM7 and Attention Deficit Disorder with Hyperactivity
 Substance-Related Disorders Antibodies  >2 publications with GRM7 and Substance-Related Disorders
 Death Antibodies  >1 publications with GRM7 and Death
 Immune System Diseases Antibodies  >1 publications with GRM7 and Immune System Diseases
 Nerve Degeneration Antibodies  >1 publications with GRM7 and Nerve Degeneration
 Brain Diseases Antibodies  >1 publications with GRM7 and Brain Diseases
 Developmental Disabilities Antibodies  >1 publications with GRM7 and Developmental Disabilities
 Disease Models, Animal Antibodies  >1 publications with GRM7 and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with GRM7 and Memory Disorders

Organs/Tissues associated with anti-GRM7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with GRM7 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000