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HSPC142 (BABAM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630476

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSPC142 (BABAM1), Polyclonal Antibody
Full Product Name
HSPC142 (BRCA1-A Complex Subunit MERIT40, Chromosome 19 Open Reading Frame 62, C19orf62, FLJ20571, Mediator of RAP80 Interactions and Targeting Subunit of 40kD, MERIT40, New Component of the BRCA1-A Complex, NBA1)
Product Gene Name
anti-BABAM1 antibody
Product Synonym Names
Anti -HSPC142 (BRCA1-A Complex Subunit MERIT40, Chromosome 19 Open Reading Frame 62, C19orf62, FLJ20571, Mediator of RAP80 Interactions and Targeting Subunit of 40kD, MERIT40, New Component of the BRCA1-A Complex, NBA1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human HSPC142.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,560 Da
OMIM
612766
3D Structure
ModBase 3D Structure for Q9NWV8
Immunogen
Synthetic peptide selected from the Center region of human HSPC142 (KLH).

Product Categories/Family for anti-BABAM1 antibody

Antibodies; Abs to DNA Replication; Repair
Applications Tested/Suitable for anti-BABAM1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-BABAM1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Immunohistochemistry (IHC) of anti-BABAM1 antibody

Formalin-fixed and paraffin-embedded human brain reacted with HSPC142 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-BABAM1 Polyclonal Antibody – Cat# MBS630476

Western Blot (WB) of anti-BABAM1 antibody

Western blot analysis of HSPC142 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane). HSPC142 (arrow) was detected using the purified Pab.
Rabbit Anti-BABAM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS630476

Flow Cytometry (FC/FACS) of anti-BABAM1 antibody

Flow cytometric analysis of MDA-MB468 cells using HSPC142 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-BABAM1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630476

Other Notes

Small volumes of anti-BABAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BABAM1 purchase

MBS630476 is an antibody targeting BABAM1. Also known as HSPC142 (BRCA1-A Complex Subunit MERIT40, Chromosome 19 Open Reading Frame 62, C19orf62, FLJ20571, Mediator of RAP80 Interactions and Targeting Subunit of 40kD, MERIT40, New Component of the BRCA1-A Complex, NBA1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BABAM1. It may not necessarily be applicable to this product.

NCBI GI #
49065478
UniProt Primary Accession #
Q9NWV8
UniProt Secondary Accession #
Q6FIA0; Q9P018; A8MQT0; B4DRY9; B4DVR1
NCBI Official Full Name
HSPC142
UniProt Protein Name
BRISC and BRCA1-A complex member 1
UniProt Synonym Protein Names
Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex
Protein Family
BRISC and BRCA1-A complex
UniProt Gene Name
BABAM1
UniProt Synonym Gene Names
C19orf62; MERIT40; NBA1
UniProt Entry Name
BABA1_HUMAN

UniProt Comments for BABAM1

NBA1: a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes. Two alternatively spliced human isoforms have been reported.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: positive regulation of DNA repair; double-strand break repair; response to ionizing radiation; chromatin modification; G2/M transition DNA damage checkpoint
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BABAM1 antibody

 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with BABAM1 and FLNA

Pathways associated with anti-BABAM1 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Organs/Tissues associated with anti-BABAM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with BABAM1 and Nerve
 Ovary Antibodies  >1 publications with BABAM1 and Ovary
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