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HADHB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6305328

HADHB encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
HADHB, Polyclonal Antibody
Full Product Name
HADHB, CT (HADHB, Trifunctional enzyme subunit beta, mitochondrial, TP-beta, 3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase) (AP)
Product Gene Name
anti-HADHB antibody
Product Synonym Names
HADHB; Trifunctional enzyme subunit beta, mitochondrial; TP-beta; 3-ketoacyl-CoA thiolase; Acetyl-CoA acyltransferase; Beta-ketothiolase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
48,880 Da
OMIM
143450
3D Structure
ModBase 3D Structure for P55084
Immunogen
HADHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321~351 amino acids from the C-terminal region of human HADHB.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-HADHB antibody

Antibodies; Enzymes; Acyltransferase
Applications Tested/Suitable for anti-HADHB antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-HADHB antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-HADHB antibody

Western blot analysis of HADHB Antibody (C-term) in Jurkat cell line lysates (35ug/lane). HADHB (arrow) was detected using the purified Pab.
Rabbit Anti-HADHB Polyclonal Antibody – Cat# MBS6305328

Flow Cytometry (FC/FACS) of anti-HADHB antibody

HADHB Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HADHB Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6305328

Product References and Citations for anti-HADHB antibody

Purevsuren, J., et al. Mol. Genet. Metab. 98(4):372-377(2009). Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008). Wang, R., et al. Zhonghua Fu Chan Ke Za Zhi 41(10):672-675(2006). Hillier, L.W., et al. Nature 434(7034):724-731(2005).

Other Notes

Small volumes of anti-HADHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HADHB purchase

MBS6305328 is an antibody targeting HADHB. Also known as HADHB, CT (HADHB, Trifunctional enzyme subunit beta, mitochondrial, TP-beta, 3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HADHB. It may not necessarily be applicable to this product.

NCBI GI #
4504327
NCBI GeneID
3032
NCBI Accession #
NP_000174.1
UniProt Primary Accession #
P55084
UniProt Secondary Accession #
O14969; Q53TA6; Q96C77; Q9H3F5; Q9T2V8; B2RB16; B4E2W0
UniProt Related Accession #
P55084
GenBank Nucleotide #
NM_000183.2
NCBI Official Full Name
trifunctional enzyme subunit beta, mitochondrial isoform 1
NCBI Official Synonym Full Names
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
NCBI Official Symbol
HADHB
NCBI Official Synonym Symbols
ECHB; MTPB; MSTP029; TP-BETA
UniProt Protein Name
Trifunctional enzyme subunit beta, mitochondrial
UniProt Synonym Protein Names
TP-betaIncluding the following 1 domains:3-ketoacyl-CoA thiolase (EC:2.3.1.16)Alternative name(s):Acetyl-CoA acyltransferase; Beta-ketothiolase
Protein Family
Trifunctional enzyme
UniProt Gene Name
HADHB
UniProt Entry Name
ECHB_HUMAN
NCBI Protein Information
trifunctional enzyme subunit beta, mitochondrial

UniProt Comments for HADHB

HADHB: Defects in HADHB are a cause of trifunctional protein deficiency (TFP deficiency). The clinical manifestations are very variable and include hypoglycemia, cardiomyopathy and sudden death. Phenotypes with mainly hepatic and neuromyopathic involvement can also be distinguished. Biochemically, TFP deficiency is defined by the loss of all three enzyme activities of the TFP complex. Belongs to the thiolase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.1.16; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Transferase

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: endoplasmic reticulum; mitochondrial envelope; mitochondrial inner membrane; mitochondrial outer membrane

Molecular Function: 3-hydroxyacyl-CoA dehydrogenase activity; enoyl-CoA hydratase activity; protein binding

Biological Process: fatty acid beta-oxidation

Disease: Trifunctional Protein Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HADHB antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies  Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
 Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway antibodies  Beta Oxidation Of Hexanoyl-CoA To Butanoyl-CoA Pathway Diagram
 Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway antibodies  Beta Oxidation Of Lauroyl-CoA To Decanoyl-CoA-CoA Pathway Diagram
 Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway antibodies  Beta Oxidation Of Myristoyl-CoA To Lauroyl-CoA Pathway Diagram
 Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies  Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
 Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway antibodies  Beta Oxidation Of Palmitoyl-CoA To Myristoyl-CoA Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Mitochondria Pathway Diagram

Diseases associated with anti-HADHB antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >11 publications with HADHB and Fatty Liver
 Liver Diseases Antibodies  >6 publications with HADHB and Liver Diseases
 Lipid Metabolism Disorders Antibodies  >6 publications with HADHB and Lipid Metabolism Disorders
 Inflammation Antibodies  >3 publications with HADHB and Inflammation
 Cardiovascular Diseases Antibodies  >3 publications with HADHB and Cardiovascular Diseases
 Insulin Resistance Antibodies  >3 publications with HADHB and Insulin Resistance
 Weight Gain Antibodies  >3 publications with HADHB and Weight Gain
 Liver Failure, Acute Antibodies  >3 publications with HADHB and Liver Failure, Acute
 Fibrosis Antibodies  >2 publications with HADHB and Fibrosis
 Necrosis Antibodies  >2 publications with HADHB and Necrosis

Organs/Tissues associated with anti-HADHB antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with HADHB and Liver
 Muscle Antibodies  >7 publications with HADHB and Muscle
 Heart Antibodies  >7 publications with HADHB and Heart
 Blood Antibodies  >6 publications with HADHB and Blood
 Adipose Tissue Antibodies  >4 publications with HADHB and Adipose Tissue
 Connective Tissue Antibodies  >3 publications with HADHB and Connective Tissue
 Skin Antibodies  >2 publications with HADHB and Skin
 Lung Antibodies  >2 publications with HADHB and Lung
 Kidney Antibodies  >2 publications with HADHB and Kidney
 Nerve Antibodies  >2 publications with HADHB and Nerve
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