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HEMGN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6306089

HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HEMGN, Polyclonal Antibody
Full Product Name
HEMGN, CT (HEMGN, EDAG, NDR, Hemogen, Erythroid differentiation-associated gene protein, Hemopoietic gene protein, Negative differentiation regulator protein) (Biotin)
Product Gene Name
anti-HEMGN antibody
Product Synonym Names
HEMGN; EDAG; NDR; Hemogen; Erythroid differentiation-associated gene protein; Hemopoietic gene protein; Negative differentiation regulator protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
3D Structure
ModBase 3D Structure for Q9BXL5
Immunogen
HEMGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-449 amino acids from the C-terminal region of human HEMGN.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-HEMGN antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-HEMGN antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-HEMGN antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-HEMGN antibody

HEMGN Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HEMGN antibody detected the HEMGN protein (arrow).
Rabbit Anti-HEMGN Polyclonal Antibody – Cat# MBS6306089

Product References and Citations for anti-HEMGN antibody

Ding, Y.L., et al. J. Cell. Biochem. 110(4):866-874(2010). Moreno, L.M., et al. Hum. Mol. Genet. 18(24):4879-4896(2009). Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009): Li, C.Y., et al. Biochim. Biophys. Acta 1779(10):606-615(2008). Ling, B., et al. Oncol. Rep. 18(3):659-664(2007).

Other Notes

Small volumes of anti-HEMGN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HEMGN purchase

MBS6306089 is an antibody targeting HEMGN. Also known as HEMGN, CT (HEMGN, EDAG, NDR, Hemogen, Erythroid differentiation-associated gene protein, Hemopoietic gene protein, Negative differentiation regulator protein) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HEMGN. It may not necessarily be applicable to this product.

NCBI GI #
37574618
NCBI GeneID
55363
NCBI Accession #
NP_932095.1
NCBI Related Accession #
NP_060907.2
UniProt Primary Accession #
Q9BXL5
UniProt Related Accession #
Q9BXL5
GenBank Nucleotide #
NP_932095.1
NCBI Official Full Name
hemogen
NCBI Official Synonym Full Names
hemogen
NCBI Official Symbol
HEMGN
NCBI Official Synonym Symbols
NDR; EDAG; CT155; EDAG-1
UniProt Protein Name
Hemogen
UniProt Synonym Protein Names
Erythroid differentiation-associated gene protein; EDAG-1; Hemopoietic gene protein; Negative differentiation regulator protein
Protein Family
Hemogen
UniProt Gene Name
HEMGN
UniProt Synonym Gene Names
EDAG; NDR; EDAG-1
NCBI Protein Information
hemogen

UniProt Comments for HEMGN

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

Research Articles on HEMGN

1. Using ex vivo culture and HSC transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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