Phosphatase, Alkaline, Bone Antibody – Sheep Polyclonal

Human bone alkaline phosphatase is a membrance-bound hydrolase enzyme expressed by osteoblast cells. Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). Although the exact biochemical function of BAP is uncertain, measurement of the serum levels of BAP can be used as a biochemical indicator of bone turnover. Conditions which present with a decrease in the level of BAP (hypophosphatasemia) include the inherited bone-deforming disorder hypophosphatasia and osteoporosis, whilst an increase in BAP (hyperphosphatasemia) is associated with Paget's disease, bone fractures and osteosarcomas.

Small volumes of anti-Phosphatase, Alkaline, Bone antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS630807 is an antibody targeting Phosphatase, Alkaline, Bone. Also known as Phosphatase, Alkaline, Human, Bone (BAP) (HRP). Reactive in Human. Host: Sheep.