HOXD10 Antibody – Rabbit Polyclonal

HOXD10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD10 are a cause of congenital vertical talus (CVT); also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: hindlimb morphogenesis; skeletal muscle development; transcription, DNA-dependent; adult locomotory behavior; neuromuscular process; multicellular organismal development; spinal cord motor neuron cell fate specification; embryonic skeletal morphogenesis; forelimb morphogenesis; anterior/posterior pattern formation; peripheral nervous system neuron development; regulation of transcription, DNA-dependent; regulation of gene expression; single fertilization; positive regulation of transcription from RNA polymerase II promoter; skeletal development; proximal/distal pattern formation; embryonic limb morphogenesis