CUGBP2 (CELF2) Antibody – Rabbit Polyclonal

RNA editing is an important mechanism for regulating genetic plasticity through the generation of alternative protein products from a single structural gene. There are two types of substitutional RNA exist in mammals, namely A-to-I and C-to-U RNA editing. The best-characterized example of C-to-U RNA editing involves the nuclear transcript encoding intestinal apolipoprotein B (apo B)). Apo B RNA editing changes a CAA to a UAA stop codon, generating a truncated protein, apoB48. The functional complex includes a minimal core composed of apobec-1 and ACF, that function as an adaptor protein by binding both the deaminase and the RNA substrate. The RNA binding proteins also include CUGBP2 which along with Apobec-1 binds to the consensus binding sequence UUUN (A/U) U, present in c-myc, VEGF and Cyclooxygenase-2 (COX2).

Small volumes of anti-CELF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS630846 is an antibody targeting CELF2. Also known as Anti-CUGBP2 (CUGBP Elav-like Family Member 2, CELF-2, Bruno-like Protein 3, CUG Triplet Repeat RNA-binding Protein 2, CUG-BP2, CUG-BP- and ETR-3-like Factor 2, ELAV-type RNA-binding Protein 3, ETR-3, Neuroblastoma Apoptosis-related RNA-binding Protein, hN. Reactive in Human. Host: Rabbit.