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STRAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630868

The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. More details

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Product Overview

Online Datasheet in PDF
Product Name
STRAP, Polyclonal Antibody
Full Product Name
STRAP, CT (Serine-threonine Kinase Receptor-associated Protein, MAP Activator With WD Repeats, MAWD, PT-WD, UNR-interacting Protein, UNRIP, WD-40 Repeat Protein PT-WD)
Product Gene Name
anti-STRAP antibody
Product Synonym Names
Anti -STRAP, CT (Serine-threonine Kinase Receptor-associated Protein, MAP Activator With WD Repeats, MAWD, PT-WD, UNR-interacting Protein, UNRIP, WD-40 Repeat Protein PT-WD)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human STRAP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
38,438 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (16035288..16056412). Location: 12p12.3
OMIM
605986
3D Structure
ModBase 3D Structure for Q9Y3F4
Immunogen
Synthetic peptide selected from the C-terminal region of human STRAP (KLH).

Product Categories/Family for anti-STRAP antibody

Antibodies; Abs to RNA Processing
Applications Tested/Suitable for anti-STRAP antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-STRAP antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-STRAP antibody

Western blot analysis of STRAP Antibody (C-term) in Hela cell line lysates (35ug/lane). STRAP (arrow) was detected using the purified Pab.
Rabbit Anti-STRAP Polyclonal Antibody – Cat# MBS630868

Immunohistochemistry (IHC) of anti-STRAP antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with STRAP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-STRAP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630868

Flow Cytometry (FC/FACS) of anti-STRAP antibody

Flow cytometric analysis of hela cells using STRAP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-STRAP Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS630868

Western Blot (WB) of anti-STRAP antibody

Western blot analysis of STRAP (arrow) using rabbit polyclonal STRAP Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the STRAP gene.
Rabbit Anti-STRAP Polyclonal Antibody, Western Blot (WB) – Cat# MBS630868

Other Notes

Small volumes of anti-STRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STRAP purchase

MBS630868 is an antibody targeting STRAP. Also known as STRAP, CT (Serine-threonine Kinase Receptor-associated Protein, MAP Activator With WD Repeats, MAWD, PT-WD, UNR-interacting Protein, UNRIP, WD-40 Repeat Protein PT-WD). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STRAP. It may not necessarily be applicable to this product.

NCBI GI #
148727341
NCBI GeneID
11171
NCBI Accession #
NP_009109.3
UniProt Primary Accession #
Q9Y3F4
UniProt Secondary Accession #
Q5TZT4; Q9NTK0; Q9UQC8; B2R5S5
UniProt Related Accession #
Q9Y3F4
GenBank Nucleotide #
NM_007178.3
NCBI Official Full Name
serine-threonine kinase receptor-associated protein
NCBI Official Synonym Full Names
serine/threonine kinase receptor associated protein
NCBI Official Symbol
STRAP
NCBI Official Synonym Symbols
MAWD; PT-WD; UNRIP
UniProt Protein Name
Serine-threonine kinase receptor-associated protein
UniProt Synonym Protein Names
MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD
Protein Family
Serine-threonine kinase receptor-associated protein
UniProt Gene Name
STRAP
UniProt Synonym Gene Names
MAWD; UNRIP
UniProt Entry Name
STRAP_HUMAN
NCBI Protein Information
serine-threonine kinase receptor-associated protein; OTTHUMP00000239479; OTTHUMP00000239480; unr-interacting protein; WD-40 repeat protein PT-WD; MAP activator with WD repeats

UniProt Comments for STRAP

STRAP: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associates with the complex in the cytoplasm but not in the nucleus. Also interacts with CSDE1/UNR and MAWBP. Interacts with PDPK1. Belongs to the WD repeat STRAP family.

Protein type: RNA splicing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; SMN complex; nucleus; cytosol

Molecular Function: protein binding; receptor binding

Biological Process: spliceosomal snRNP biogenesis; maintenance of gastrointestinal epithelium; transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of epithelial cell proliferation
Show more

Research Articles on STRAP

1. B-MYB acts as a positive regulator of STRAP

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STRAP antibody

 Reference Product  PubMed Publications
 SMAD7 antibody  >8 publications with STRAP and SMAD7
 SMAD3 antibody  >6 publications with STRAP and SMAD3
 GEMIN7 antibody  >4 publications with STRAP and GEMIN7
 SMAD2 antibody  >3 publications with STRAP and SMAD2
 GEMIN6 antibody  >3 publications with STRAP and GEMIN6

Pathways associated with anti-STRAP antibody

 Products by Pathway  Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-STRAP antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >107 publications with STRAP and Nervous System Diseases
 Pain Antibodies  >65 publications with STRAP and Pain
 Carcinoma Antibodies  >42 publications with STRAP and Carcinoma
 Thyroid Diseases Antibodies  >40 publications with STRAP and Thyroid Diseases
 Thyroid Neoplasms Antibodies  >35 publications with STRAP and Thyroid Neoplasms
 Recurrence Antibodies  >27 publications with STRAP and Recurrence
 Female Urogenital Diseases Antibodies  >21 publications with STRAP and Female Urogenital Diseases
 Fibrosis Antibodies  >20 publications with STRAP and Fibrosis
 Congenital Abnormalities Antibodies  >20 publications with STRAP and Congenital Abnormalities
 Hemorrhage Antibodies  >18 publications with STRAP and Hemorrhage

Organs/Tissues associated with anti-STRAP antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >310 publications with STRAP and Muscle
 Bone Antibodies  >127 publications with STRAP and Bone
 Thyroid Antibodies  >85 publications with STRAP and Thyroid
 Nerve Antibodies  >79 publications with STRAP and Nerve
 Skin Antibodies  >77 publications with STRAP and Skin
 Larynx Antibodies  >69 publications with STRAP and Larynx
 Blood Antibodies  >62 publications with STRAP and Blood
 Vascular Antibodies  >57 publications with STRAP and Vascular
 Trachea Antibodies  >44 publications with STRAP and Trachea
 Heart Antibodies  >35 publications with STRAP and Heart
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