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Connexin 37 (GJA4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630962

Gap junctions permit direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular communication. Gap junction channels consist of connexin protein subunits… More details

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Product Overview

Online Datasheet in PDF
Product Name
Connexin 37 (GJA4), Polyclonal Antibody
Full Product Name
Connexin 37, CT (Gap Junction alpha-4 Protein, GJA4, Connexin-37, Cx37)
Product Gene Name
Product Synonym Names
Anti -Connexin 37, CT (Gap Junction alpha-4 Protein, GJA4, Connexin-37, Cx37)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human GJA4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,414 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (35258599..35261348). Location: 1p35.1
OMIM
121012
3D Structure
ModBase 3D Structure for P35212
Immunogen
Synthetic peptide selected from the C-terminal region of human GJA4 (KLH).
Applications Tested/Suitable for anti-GJA4 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-GJA4 antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-GJA4 antibody

GJA4 Antibody (K317).Connexin western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the GJA4 antibody detected the GJA4 protein (arrow).
Rabbit Anti-GJA4 Polyclonal Antibody – Cat# MBS630962

Immunohistochemistry (IHC) of anti-GJA4 antibody

Connexin 37 Antibody (GJA4) (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Connexin 37 Antibody (GJA4) (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GJA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630962

Other Notes

Small volumes of anti-GJA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GJA4 purchase

MBS630962 is an antibody targeting GJA4. Also known as Connexin 37, CT (Gap Junction alpha-4 Protein, GJA4, Connexin-37, Cx37). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GJA4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
connexin 37
NCBI Official Synonym Full Names
gap junction protein, alpha 4, 37kDa
NCBI Official Symbol
GJA4
NCBI Official Synonym Symbols
CX37
UniProt Protein Name
Gap junction alpha-4 protein
UniProt Synonym Protein Names
Connexin-37
UniProt Gene Name
GJA4
UniProt Entry Name
CXA4_HUMAN
NCBI Protein Information
gap junction alpha-4 protein; connexin 37; connexin-37; OTTHUMP00000004181; OTTHUMP00000004182

NCBI Summary for GJA4

This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq]
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UniProt Comments for GJA4

GJA4: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein type: Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: connexon complex; integral to plasma membrane; gap junction

Molecular Function: protein binding

Biological Process: intercellular junction assembly; blood vessel development; cell-cell signaling; transport; calcium ion transport; response to pain
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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