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Pantothenate Kinase 3 (PANK3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630993

PANK3 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pantothenate Kinase 3 (PANK3), Polyclonal Antibody
Full Product Name
Pantothenate Kinase 3, NT (Pantothenic Acid Kinase 3, PANK3, hPanK3, DKFZp686O22247, FLJ12899, MGC16863)
Product Gene Name
anti-PANK3 antibody
Product Synonym Names
Anti -Pantothenate Kinase 3, NT (Pantothenic Acid Kinase 3, PANK3, hPanK3, DKFZp686O22247, FLJ12899, MGC16863)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PANK3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
41,094 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (167982630..168006588, complement). Location: 5q34
OMIM
606161
3D Structure
ModBase 3D Structure for Q9H999
Immunogen
Synthetic peptide selected from the N-terminal region of human PANK3 (KLH).

Product Categories/Family for anti-PANK3 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PANK3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PANK3 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-PANK3 antibody

Western blot analysis of anti-PANK3 Antibody (N-term) in NCI-H460 cell line lysates (35ug/lane). PANK3(arrow) was detected using the purified Pab.
Rabbit Anti-PANK3 Polyclonal Antibody – Cat# MBS630993

Immunohistochemistry (IHC) of anti-PANK3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-PANK3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630993

Other Notes

Small volumes of anti-PANK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PANK3 purchase

MBS630993 is an antibody targeting PANK3. Also known as Pantothenate Kinase 3, NT (Pantothenic Acid Kinase 3, PANK3, hPanK3, DKFZp686O22247, FLJ12899, MGC16863). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PANK3. It may not necessarily be applicable to this product.

NCBI GI #
13375789
NCBI GeneID
79646
NCBI Accession #
NP_078870.1
UniProt Primary Accession #
Q9H999
UniProt Secondary Accession #
Q53FJ9; Q7RTX4; D3DQL1
UniProt Related Accession #
Q9H999
GenBank Nucleotide #
NM_024594.3
NCBI Official Full Name
pantothenate kinase 3
NCBI Official Synonym Full Names
pantothenate kinase 3
NCBI Official Symbol
PANK3
NCBI Official Synonym Symbols
FLJ12899; MGC16863; DKFZp686O22247
UniProt Protein Name
Pantothenate kinase 3
UniProt Synonym Protein Names
Pantothenic acid kinase 3
Protein Family
Pantothenate kinase
UniProt Gene Name
PANK3
UniProt Entry Name
PANK3_HUMAN
NCBI Protein Information
pantothenate kinase 3; hPanK3; OTTHUMP00000160961; pantothenic acid kinase 3

NCBI Summary for PANK3

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq]
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UniProt Comments for PANK3

PANK3: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family.

Protein type: EC 2.7.1.33; Kinase, other; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm

Molecular Function: pantothenate kinase activity; ATP binding

Biological Process: coenzyme A biosynthetic process; phosphorylation
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Research Articles on PANK3

1. analysis of the homodimeric structures of the catalytic cores of PanK1alpha and PanK3 in complex with acetyl-CoA and the the structural effects of the PanK2 mutations that have been implicated in neurodegeneration

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PANK3 antibody

 Products by Pathway  Pathway Diagram
 Coenzyme A Biosynthesis Pathway antibodies  Coenzyme A Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Vitamin B5 (pantothenate) Metabolism Pathway antibodies  Vitamin B5 (pantothenate) Metabolism Pathway Diagram

Diseases associated with anti-PANK3 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with PANK3 and Liver Diseases
 Movement Disorders Antibodies  >1 publications with PANK3 and Movement Disorders
 Brain Diseases Antibodies  >1 publications with PANK3 and Brain Diseases

Organs/Tissues associated with anti-PANK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with PANK3 and Liver
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