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VWC2 Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631007

Brorin (also VWC2, von Willebrand Factor C domain-containing protein 2) is a secreted, 48-49 kD member of the chordin family of proteins. It is expressed by neurons in multiple sites, and serves to sequester BMP family proteins such as BMP-2 and BMP-6. BMP… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VWC2, Polyclonal Antibody
Full Product Name
VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434)
Product Gene Name
Product Synonym Names
Anti -VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with sterile PBS.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Brorin. Species sequence homology: mouse (90%).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
35,282 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (49813257..49952138). Location: 7p12.2
OMIM
611108
3D Structure
ModBase 3D Structure for Q2TAL6
Immunogen
NS0-derived, recombinant human Brorin (aa28-325; Accession #Q2TAL6).

Product Categories/Family for anti-VWC2 antibody

Applications Tested/Suitable for anti-VWC2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-VWC2 antibody
Dilution: ELISA:0.5-1ug/ml
Western Blot:1ug/ml

Other Notes

Small volumes of anti-VWC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VWC2 purchase

MBS631007 is an antibody targeting VWC2. Also known as VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for VWC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Von Willebrand factor C domain containing 2
NCBI Official Synonym Full Names
von Willebrand factor C domain containing 2
NCBI Official Symbol
VWC2
NCBI Official Synonym Symbols
UNQ739; PSST739; MGC131845
UniProt Protein Name
Brorin
UniProt Synonym Protein Names
Brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2
Protein Family
UniProt Gene Name
VWC2
UniProt Entry Name
VWC2_HUMAN
NCBI Protein Information
brorin; OTTHUMP00000159581; brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2

NCBI Summary for VWC2

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.

UniProt Comments for VWC2

PSST739: BMP antagonist which may play a role in neural development. Promotes cell adhesion.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: extracellular space; basement membrane; synapse; cell junction

Biological Process: positive regulation of neuron differentiation; negative regulation of BMP signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-VWC2 antibody

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