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Fragilis (IFITM3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631014

The family of interferon-induced transmembrane protein (Ifitm/mil/fragilis) cell surface proteins may modulate cell adhesion and influence cell differentiation. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fragilis (Ifitm3), Polyclonal Antibody
Full Product Name
Fragilis, ID (Interferon-induced Transmembrane Protein 3, Interferon-inducible Protein 1-8U, IFITM3)
Product Gene Name
anti-Ifitm3 antibody
Product Synonym Names
Anti -Fragilis, ID (Interferon-induced Transmembrane Protein 3, Interferon-inducible Protein 1-8U, IFITM3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human IFITM3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
14,954 Da
Chromosome Location
Chromosome: 7; NC_000073.5 (148195489..148196643, complement). Location: 7 F5; 7
3D Structure
ModBase 3D Structure for Q9CQW9
Immunogen
Synthetic peptide selected from the Center region of human IFITM3 (KLH).

Product Categories/Family for anti-Ifitm3 antibody

Antibodies; Abs to Interferon
Applications Tested/Suitable for anti-Ifitm3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Ifitm3 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-Ifitm3 antibody

Western blot analysis of IFITM3 (arrow) using rabbit polyclonal IFITM3 Antibody (C-term) .293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IFITM3 gene (Lane 2)
Rabbit Anti-IFITM3 Polyclonal Antibody – Cat# MBS631014

Western Blot (WB) of anti-Ifitm3 antibody

Western blot analysis of anti-IFITM3 Antibody (Center) in Hela cell line lysates (35ug/lane). IFITM3(arrow) was detected using the purified Pab.
Rabbit Anti-IFITM3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS631014

Other Notes

Small volumes of anti-Ifitm3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ifitm3 purchase

MBS631014 is an antibody targeting Ifitm3. Also known as Fragilis, ID (Interferon-induced Transmembrane Protein 3, Interferon-inducible Protein 1-8U, IFITM3). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ifitm3. It may not necessarily be applicable to this product.

NCBI GI #
20086231
NCBI GeneID
66141
UniProt Primary Accession #
Q9CQW9
UniProt Secondary Accession #
Q9D8L6
UniProt Related Accession #
Q9CQW9
NCBI Official Full Name
fragilis
NCBI Official Synonym Full Names
interferon induced transmembrane protein 3
NCBI Official Symbol
Ifitm3
NCBI Official Synonym Symbols
Fgls; IP15; Cd225; mil-1; Cdw217; 1110004C05Rik
UniProt Protein Name
Interferon-induced transmembrane protein 3
UniProt Synonym Protein Names
Fragilis protein; Interferon-inducible protein 15; Mouse ifitm-like protein 1
Protein Family
Interferon-induced transmembrane protein
UniProt Gene Name
Ifitm3
UniProt Entry Name
IFM3_MOUSE
NCBI Protein Information
interferon-induced transmembrane protein 3; fragilis protein; ifitm-like protein 1; interferon-inducible protein 15

UniProt Comments for Ifitm3

IFITM3: IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. Interacts with SPP1; the interaction reduces OPN expression. By IFN-alpha and IFNG/IFN-gamma. Belongs to the CD225/Dispanin family.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: cell surface; membrane; endoplasmic reticulum; lysosome; apical part of cell; cytoplasmic membrane-bound vesicle; cytoplasm; integral to membrane; plasma membrane; nucleus; endosome

Biological Process: receptor-mediated endocytosis; negative regulation of cell proliferation; negative regulation of viral transcription; negative regulation of viral genome replication; immune system process; negative regulation of virion penetration into host cell; response to biotic stimulus; response to virus; innate immune response; defense response to virus
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Research Articles on Ifitm3

1. Targeted chromosome engineering was used to generate mutants which either lack the entire Ifitm locus or carry a disrupted Ifitm3 gene only.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ifitm3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-Ifitm3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with Ifitm3 and Neoplasms
 Intestinal Diseases Antibodies  >5 publications with Ifitm3 and Intestinal Diseases
 Inflammation Antibodies  >4 publications with Ifitm3 and Inflammation
 Colitis, Ulcerative Antibodies  >3 publications with Ifitm3 and Colitis, Ulcerative
 Hepatitis Antibodies  >3 publications with Ifitm3 and Hepatitis
 Inflammatory Bowel Diseases Antibodies  >3 publications with Ifitm3 and Inflammatory Bowel Diseases
 Colorectal Neoplasms Antibodies  >3 publications with Ifitm3 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >3 publications with Ifitm3 and Colonic Neoplasms
 Influenza, Human Antibodies  >3 publications with Ifitm3 and Influenza, Human
 Colitis Antibodies  >3 publications with Ifitm3 and Colitis

Organs/Tissues associated with anti-Ifitm3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with Ifitm3 and Brain
 Intestine Antibodies  >4 publications with Ifitm3 and Intestine
 Uterus Antibodies  >3 publications with Ifitm3 and Uterus
 Blood Antibodies  >3 publications with Ifitm3 and Blood
 Lung Antibodies  >3 publications with Ifitm3 and Lung
 Embryonic Tissue Antibodies  >3 publications with Ifitm3 and Embryonic Tissue
 Heart Antibodies  >2 publications with Ifitm3 and Heart
 Bone Antibodies  >2 publications with Ifitm3 and Bone
 Muscle Antibodies  >1 publications with Ifitm3 and Muscle
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