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CLASP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631037

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed… More details

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Product Overview

Online Datasheet in PDF
Product Name
CLASP1, Polyclonal Antibody
Full Product Name
CLASP1, CT (CLIP-associating Protein 1, Cytoplasmic Linker-associated Protein 1, Multiple Asters Homolog 1, Protein Orbit Homolog 1, hOrbit1, KIAA0622, MAST1)
Product Gene Name
anti-CLASP1 antibody
Product Synonym Names
Anti -CLASP1, CT (CLIP-associating Protein 1, Cytoplasmic Linker-associated Protein 1, Multiple Asters Homolog 1, Protein Orbit Homolog 1, hOrbit1, KIAA0622, MAST1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CLASP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,242 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (122095352..122407052, complement). Location: 2q14.2-q14.3
3D Structure
ModBase 3D Structure for Q68D09
Immunogen
Synthetic peptide selected from the C-terminal region of human CLASP1 (KLH).

Product Categories/Family for anti-CLASP1 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-CLASP1 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-CLASP1 antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:10-1:50

Other Notes

Small volumes of anti-CLASP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLASP1 purchase

MBS631037 is an antibody targeting CLASP1. Also known as CLASP1, CT (CLIP-associating Protein 1, Cytoplasmic Linker-associated Protein 1, Multiple Asters Homolog 1, Protein Orbit Homolog 1, hOrbit1, KIAA0622, MAST1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CLASP1. It may not necessarily be applicable to this product.

NCBI GI #
214010173
NCBI GeneID
23332
NCBI Accession #
NP_001135745.1
UniProt Primary Accession #
Q68D09
UniProt Related Accession #
Q68D09; Q6TAR3; Q7Z460
GenBank Nucleotide #
NM_001142273.1
NCBI Official Full Name
CLIP-associating protein 1 isoform 2
NCBI Official Synonym Full Names
cytoplasmic linker associated protein 1
NCBI Official Symbol
CLASP1
NCBI Official Synonym Symbols
MAST1; FLJ33821; FLJ41222; KIAA0622; MGC131895; DKFZp686D1968; DKFZp686H2039
UniProt Protein Name
Putative uncharacterized protein DKFZp686D1968
Protein Family
CLIP-associating protein
UniProt Gene Name
DKFZp686D1968
UniProt Entry Name
Q68D09_HUMAN
NCBI Protein Information
CLIP-associating protein 1; multiple asters 1; OTTHUMP00000203754; OTTHUMP00000207290; protein Orbit homolog 1; multiple asters homolog 1; cytoplasmic linker-associated protein 1

UniProt Comments for CLASP1

CLASP1: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Belongs to the CLASP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q14.2-q14.3

Cellular Component: kinetochore microtubule; kinetochore; Golgi apparatus; centrosome; membrane; spindle microtubule; cytoplasmic microtubule; cortical microtubule cytoskeleton; cell cortex; cytosol

Molecular Function: kinetochore binding; microtubule plus-end binding; protein binding; microtubule binding

Biological Process: microtubule organizing center organization and biogenesis; axon guidance; negative regulation of microtubule depolymerization; organelle organization and biogenesis; negative regulation of microtubule polymerization or depolymerization; establishment and/or maintenance of cell polarity; establishment of spindle orientation; microtubule cytoskeleton organization and biogenesis; microtubule nucleation; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule bundle formation; exit from mitosis
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Research Articles on CLASP1

1. Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLASP1 antibody

 Reference Product  PubMed Publications
 MAPRE1 antibody  >1 publications with CLASP1 and MAPRE1

Pathways associated with anti-CLASP1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram

Diseases associated with anti-CLASP1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with CLASP1 and Nervous System Diseases
 Fetal Death Antibodies  >1 publications with CLASP1 and Fetal Death

Organs/Tissues associated with anti-CLASP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with CLASP1 and Brain
 Bone Antibodies  >1 publications with CLASP1 and Bone
 Blood Antibodies  >1 publications with CLASP1 and Blood
 Eye Antibodies  >1 publications with CLASP1 and Eye
 Mammary Gland Antibodies  >1 publications with CLASP1 and Mammary Gland
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