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CTDP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631073

CTDP1 is a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA… More details

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Product Overview

Online Datasheet in PDF
Product Name
CTDP1, Polyclonal Antibody
Full Product Name
CTDP1, NT (RNA Polymerase II Subunit A C-terminal Domain Phosphatase, TFIIF-associating CTD Phosphatase, FCP1)
Product Gene Name
anti-CTDP1 antibody
Product Synonym Names
Anti -CTDP1, NT (RNA Polymerase II Subunit A C-terminal Domain Phosphatase, TFIIF-associating CTD Phosphatase, FCP1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CTDP1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
104,399 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (77439801..77514507). Location: 18q23
OMIM
604168
3D Structure
ModBase 3D Structure for Q9Y5B0
Immunogen
Synthetic peptide selected from the N-terminal region of human CTDP1 (KLH).

Product Categories/Family for anti-CTDP1 antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-CTDP1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CTDP1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CTDP1 antibody

Western blot analysis of CTDP1 Antibody (N-term) in 293 cell line lysates (35ug/lane). CTDP1 (arrow) was detected using the purified Pab.
Rabbit Anti-CTDP1 Polyclonal Antibody – Cat# MBS631073

Immunohistochemistry (IHC) of anti-CTDP1 antibody

Formalin-fixed and paraffin-embedded human brain tissue with CTDP1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CTDP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS631073

Flow Cytometry (FC/FACS) of anti-CTDP1 antibody

Flow cytometric analysis of WiDr cells using CTDP1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CTDP1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS631073

Other Notes

Small volumes of anti-CTDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTDP1 purchase

MBS631073 is an antibody targeting CTDP1. Also known as CTDP1, NT (RNA Polymerase II Subunit A C-terminal Domain Phosphatase, TFIIF-associating CTD Phosphatase, FCP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTDP1. It may not necessarily be applicable to this product.

NCBI GI #
30962890
NCBI GeneID
9150
UniProt Primary Accession #
Q9Y5B0
UniProt Secondary Accession #
Q7Z644; Q96BZ1; Q9Y6F5; A8MY97
UniProt Related Accession #
Q9Y5B0
NCBI Official Full Name
CTDP1 protein
NCBI Official Synonym Full Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
NCBI Official Symbol
CTDP1
NCBI Official Synonym Symbols
FCP1; CCFDN
UniProt Protein Name
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Synonym Protein Names
TFIIF-associating CTD phosphatase
UniProt Gene Name
CTDP1
UniProt Synonym Gene Names
FCP1
UniProt Entry Name
CTDP1_HUMAN
NCBI Protein Information
RNA polymerase II subunit A C-terminal domain phosphatase; OTTHUMP00000163841; OTTHUMP00000163842; serine phosphatase FCP1a; TFIIF-associating CTD phosphatase 1; CTD of POLR2A, phosphatase of, subunit 1; transcription factor IIF-associating CTD phosphatase 1

NCBI Summary for CTDP1

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
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UniProt Comments for CTDP1

CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: nucleoplasm; spindle pole; centrosome; cytoplasm; spindle; spindle midzone; midbody; actin cytoskeleton

Molecular Function: DNA-directed RNA polymerase activity; CTD phosphatase activity

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; cell division; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; protein amino acid dephosphorylation; exit from mitosis

Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
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Research Articles on CTDP1

1. NMR assignments for C terminal region

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CTDP1 antibody

 Products by Pathway  Pathway Diagram
 Abortive Elongation Of HIV-1 Transcript In The Absence Of Tat Pathway antibodies  Abortive Elongation Of HIV-1 Transcript In The Absence Of Tat Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Formation And Maturation Of MRNA Transcript Pathway antibodies  Formation And Maturation Of MRNA Transcript Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Formation Of The Early Elongation Complex Pathway antibodies  Formation Of The Early Elongation Complex Pathway Diagram
 Formation Of The HIV-1 Early Elongation Complex Pathway antibodies  Formation Of The HIV-1 Early Elongation Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram

Diseases associated with anti-CTDP1 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >7 publications with CTDP1 and Congenital Abnormalities
 CONGENITAL CATARACTS, FACIAL DYSMORPHISM, AND NEUROPATHY Antibodies  >6 publications with CTDP1 and CONGENITAL CATARACTS, FACIAL DYSMORPHISM, AND NEUROPATHY
 Hypogonadism Antibodies  >4 publications with CTDP1 and Hypogonadism
 Neoplasms Antibodies  >1 publications with CTDP1 and Neoplasms
 Myocardial Ischemia Antibodies  >1 publications with CTDP1 and Myocardial Ischemia
 Necrosis Antibodies  >1 publications with CTDP1 and Necrosis
 Edema Antibodies  >1 publications with CTDP1 and Edema

Organs/Tissues associated with anti-CTDP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with CTDP1 and Brain
 Bone Antibodies  >1 publications with CTDP1 and Bone
 Eye Antibodies  >1 publications with CTDP1 and Eye
 Blood Antibodies  >1 publications with CTDP1 and Blood
 Muscle Antibodies  >1 publications with CTDP1 and Muscle
 Lung Antibodies  >1 publications with CTDP1 and Lung
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