Rabbit Anti-IQCB1 Polyclonal Antibody – Cat# MBS6310761

Western blot analysis of MBS6003852 in Ramos cell line lysates (35ug/lane). This demonstrates the IQCB1 antibody detected the IQCB1 protein (arrow).

IQCB1 Antibody – Rabbit Polyclonal

Name: IQCB1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6310761
Price: 1120 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6310761

$1120 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IQCB1, Polyclonal Antibody

Full Product Name

IQCB1, ID (IQCB1, KIAA0036, NPHP5, IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein) (PE)

Product Gene Name

anti-IQCB1 antibody

Product Synonym Names

IQCB1; KIAA0036; NPHP5; IQ calmodulin-binding motif-containing protein 1; Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human IQCB1.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

609237

3D Structure

ModBase 3D Structure for Q15051

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 384-411 in the central region of human IQCB1, UniProt Accession #Q15051.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-IQCB1 antibody

Antibodies; Calmodulin

Applications Tested/Suitable for anti-IQCB1 antibody

Western Blot (WB), FLISA

Application Notes for anti-IQCB1 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-IQCB1 antibody

Hildebrandt, F., et al. J. Am. Soc. Nephrol. 20(1):23-35(2009)Schafer, T., et al. Hum. Mol. Genet. 17(23):3655-3662(2008). Luo, X., et al. Cancer Res. 65(23):10725-10733(2005). le Maire, A., et al. Proteins 59(2):347-355(2005). Mollet, G., et al. Hum. Mol. Genet. 14(5):645-656(2005).

Other Notes

Small volumes of anti-IQCB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IQCB1 purchase

MBS6310761 is an antibody targeting IQCB1. Also known as IQCB1, ID (IQCB1, KIAA0036, NPHP5, IQ calmodulin-binding motif-containing protein 1, Nephrocystin-5, p53 and DNA damage-regulated IQ motif protein) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IQCB1. It may not necessarily be applicable to this product.

NCBI GI #

170014680

NCBI GeneID

9657

NCBI Accession #

NP_001018865.2

NCBI Related Accession #

NP_001018864.2

UniProt Primary Accession #

Q15051

UniProt Related Accession #

Q15051

GenBank Nucleotide #

NP_001018865.2

NCBI Official Full Name

IQ calmodulin-binding motif-containing protein 1 isoform c

NCBI Official Synonym Full Names

IQ motif containing B1

NCBI Official Symbol

IQCB1

NCBI Official Synonym Symbols

PIQ; NPHP5; SLSN5

UniProt Protein Name

IQ calmodulin-binding motif-containing protein 1

UniProt Synonym Protein Names

Nephrocystin-5; p53 and DNA damage-regulated IQ motif protein

Protein Family

IQ calmodulin-binding motif-containing protein

UniProt Gene Name

IQCB1

UniProt Synonym Gene Names

KIAA0036; NPHP5; PIQ

UniProt Entry Name

IQCB1_HUMAN

NCBI Protein Information

IQ calmodulin-binding motif-containing protein 1

NCBI Summary for IQCB1

This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Jan 2016]

UniProt Comments for IQCB1

IQCB1: Involved in ciliogenesis. Defects in IQCB1 are the cause of Senior-Loken syndrome type 5 (SLSN5). SLSN is a renal-retinal disorder, characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q13.33|3q21.1

Cellular Component: nucleoplasm; microtubule cytoskeleton; centrosome; intercellular bridge; photoreceptor outer segment; cytosol; photoreceptor connecting cilium

Molecular Function: calmodulin binding; protein binding; enzyme binding

Biological Process: organelle organization and biogenesis; photoreceptor cell maintenance; cilium biogenesis; maintenance of organ identity

Disease: Senior-loken Syndrome 5

Research Articles on IQCB1

1. During ciliogenesis, the mother centriole transforms into a basal body competent to nucleate a cilium. The mother centriole and basal body possess sub-distal appendages (SDAs) and basal feet (BF), respectively. SDAs are distinguishable from BF and the protein NPHP5 is a novel SDA and BF component. NPHP5 regulates BF assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.