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JMJD2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6311664

KDM4B is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. It does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20' and only able to demethylate trimethylated H3… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JMJD2B, Polyclonal Antibody
Full Product Name
JMJD2B, NT (KDM4B, JHDM3B, JMJD2B, KIAA0876, Lysine-specific demethylase 4B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B) (AP)
Product Gene Name
anti-JMJD2B antibody
Product Synonym Gene Name
KDM4B
Product Synonym Names
KDM4B; JHDM3B; JMJD2B; KIAA0876; Lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
122kDa
OMIM
609765
3D Structure
ModBase 3D Structure for O94953
Immunogen
JMJD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the N-terminal region of human JMJD2B.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-JMJD2B antibody

Antibodies; Enzymes; Demethylase
Applications Tested/Suitable for anti-JMJD2B antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-JMJD2B antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-JMJD2B antibody

JMJD2B Antibody (N-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the JMJD2B antibody detected the JMJD2B protein (arrow).
Rabbit Anti-JMJD2B Polyclonal Antibody – Cat# MBS6311664

Product References and Citations for anti-JMJD2B antibody

Yang, J., et al. Cancer Res. 70(16):6456-6466(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Beyer, S., et al. J. Biol. Chem. 283(52):36542-36552(2008). Pollard, P.J., et al. Biochem. J. 416(3):387-394(2008). Katoh, Y., et al. Int. J. Mol. Med. 20(2):269-273(2007).

Other Notes

Small volumes of anti-JMJD2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD2B purchase

MBS6311664 is an antibody targeting JMJD2B. Also known as JMJD2B, NT (KDM4B, JHDM3B, JMJD2B, KIAA0876, Lysine-specific demethylase 4B, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD2B. It may not necessarily be applicable to this product.

NCBI GI #
45504380
NCBI GeneID
23030
NCBI Accession #
NP_055830
UniProt Primary Accession #
O94953
UniProt Related Accession #
O94953
GenBank Nucleotide #
NM_015015
NCBI Official Full Name
lysine-specific demethylase 4B
NCBI Official Synonym Full Names
lysine demethylase 4B
NCBI Official Symbol
KDM4B
NCBI Official Synonym Symbols
JMJD2B; TDRD14B
UniProt Protein Name
Lysine-specific demethylase 4B
UniProt Synonym Protein Names
JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B
UniProt Gene Name
KDM4B
UniProt Synonym Gene Names
JHDM3B; JMJD2B; KIAA0876
UniProt Entry Name
KDM4B_HUMAN
NCBI Protein Information
lysine-specific demethylase 4B

UniProt Comments for JMJD2B

JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; focal adhesion; nucleus; cell junction

Molecular Function: dioxygenase activity; zinc ion binding

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification
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Research Articles on JMJD2B

1. findings illustrate the significance of CREB-KDM4B-STAT3 signaling cascade in DNA damage response, and highlight that KDM4B may potentially be a novel oncotarget for colorectal cancer radiotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-JMJD2B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with JMJD2B and Neoplasms
 Breast Neoplasms Antibodies  >4 publications with JMJD2B and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >3 publications with JMJD2B and Gastrointestinal Diseases
 Cardiovascular Diseases Antibodies  >1 publications with JMJD2B and Cardiovascular Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with JMJD2B and Urinary Bladder Neoplasms
 Multiple Myeloma Antibodies  >1 publications with JMJD2B and Multiple Myeloma
 Alopecia Antibodies  >1 publications with JMJD2B and Alopecia
 Drug Toxicity Antibodies  >1 publications with JMJD2B and Drug Toxicity
 Hematologic Diseases Antibodies  >1 publications with JMJD2B and Hematologic Diseases
 Adenocarcinoma Antibodies  >1 publications with JMJD2B and Adenocarcinoma

Organs/Tissues associated with anti-JMJD2B antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >3 publications with JMJD2B and Prostate
 Lung Antibodies  >2 publications with JMJD2B and Lung
 Stomach Antibodies  >2 publications with JMJD2B and Stomach
 Bladder Antibodies  >1 publications with JMJD2B and Bladder
 Liver Antibodies  >1 publications with JMJD2B and Liver
 Bone Marrow Antibodies  >1 publications with JMJD2B and Bone Marrow
 Kidney Antibodies  >1 publications with JMJD2B and Kidney
 Blood Antibodies  >1 publications with JMJD2B and Blood
 Testis Antibodies  >1 publications with JMJD2B and Testis
 Bone Antibodies  >1 publications with JMJD2B and Bone
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