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JMJD2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6311709

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting… More details

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Product Overview

Online Datasheet in PDF
Product Name
JMJD2C, Polyclonal Antibody
Full Product Name
JMJD2C, CT (KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780, Lysine-specific demethylase 4C, Gene amplified in squamous cell carcinoma 1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C) (APC)
Product Gene Name
anti-JMJD2C antibody
Product Synonym Gene Name
KDM4C
Product Synonym Names
KDM4C; GASC1; JHDM3C; JMJD2C; KIAA0780; Lysine-specific demethylase 4C; Gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
94,376 Da
OMIM
605469
3D Structure
ModBase 3D Structure for Q9H3R0
Immunogen
JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1030-1056 amino acids from the C-terminal region of human JMJD2C.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-JMJD2C antibody

Antibodies; Enzymes; Demethylase
Applications Tested/Suitable for anti-JMJD2C antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-JMJD2C antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-JMJD2C antibody

JMJD2C Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the JMJD2C antibody detected the JMJD2C protein (arrow).
Rabbit Anti-JMJD2C Polyclonal Antibody – Cat# MBS6311709

Flow Cytometry (FC/FACS) of anti-JMJD2C antibody

JMJD2C Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-JMJD2C Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6311709

Product References and Citations for anti-JMJD2C antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Suikki, H.E., et al. Prostate 70(8):889-898(2010). Kantojarvi, K., et al. Psychiatr. Genet. 20(3):102-108(2010). Liu, G., et al. Oncogene 28(50):4491-4500(2009). Canova, C., et al. Cancer Res. 69(7):2956-2965(2009).

Other Notes

Small volumes of anti-JMJD2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD2C purchase

MBS6311709 is an antibody targeting JMJD2C. Also known as JMJD2C, CT (KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780, Lysine-specific demethylase 4C, Gene amplified in squamous cell carcinoma 1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD2C. It may not necessarily be applicable to this product.

NCBI GI #
226442893
NCBI GeneID
23081
NCBI Accession #
NP_001140167.1
NCBI Related Accession #
NP_001140166.1; NP_001140168.1
UniProt Primary Accession #
Q9H3R0
UniProt Secondary Accession #
O94877; Q2M3M0; Q5JUC9; Q5VYJ2; Q5VYJ3; B4E1Y4; B7ZL46; F5H347; F5H7P0
UniProt Related Accession #
Q9H3R0
GenBank Nucleotide #
NM_001146695.1
NCBI Official Full Name
lysine-specific demethylase 4C isoform 3
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 4C
NCBI Official Symbol
KDM4C
NCBI Official Synonym Symbols
GASC1; JHDM3C; JMJD2C; TDRD14C
UniProt Protein Name
Lysine-specific demethylase 4C
UniProt Synonym Protein Names
Gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C
UniProt Gene Name
KDM4C
UniProt Synonym Gene Names
GASC1; JHDM3C; JMJD2C; KIAA0780
UniProt Entry Name
KDM4C_HUMAN
NCBI Protein Information
lysine-specific demethylase 4C

NCBI Summary for JMJD2C

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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Research Articles on JMJD2C

1. Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase JMJD2C affects the prognosis of breast cancer by altering caspase-3 cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JMJD2C antibody

 Reference Product  PubMed Publications
 KDM1A antibody  >10 publications with JMJD2C and KDM1A
 KDM3A antibody  >4 publications with JMJD2C and KDM3A
 NANOG antibody  >3 publications with JMJD2C and NANOG
 IP6K1 antibody  >1 publications with JMJD2C and IP6K1

Pathways associated with anti-JMJD2C antibody

 Products by Pathway  Pathway Diagram
 Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway antibodies  Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate PKNs Pathway antibodies  RHO GTPases Activate PKNs Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with anti-JMJD2C antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >8 publications with JMJD2C and Breast Neoplasms
 Lung Neoplasms Antibodies  >5 publications with JMJD2C and Lung Neoplasms
 Adenocarcinoma Antibodies  >4 publications with JMJD2C and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >3 publications with JMJD2C and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >3 publications with JMJD2C and Lung Diseases
 Substance Withdrawal Syndrome Antibodies  >1 publications with JMJD2C and Substance Withdrawal Syndrome
 Kidney Diseases Antibodies  >1 publications with JMJD2C and Kidney Diseases
 Colonic Neoplasms Antibodies  >1 publications with JMJD2C and Colonic Neoplasms
 Hyperplasia Antibodies  >1 publications with JMJD2C and Hyperplasia
 Inflammation Antibodies  >1 publications with JMJD2C and Inflammation

Organs/Tissues associated with anti-JMJD2C antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >11 publications with JMJD2C and Prostate
 Lung Antibodies  >5 publications with JMJD2C and Lung
 Skin Antibodies  >2 publications with JMJD2C and Skin
 Blood Antibodies  >2 publications with JMJD2C and Blood
 Lymph Antibodies  >1 publications with JMJD2C and Lymph
 Kidney Antibodies  >1 publications with JMJD2C and Kidney
 Lymph Node Antibodies  >1 publications with JMJD2C and Lymph Node
 Liver Antibodies  >1 publications with JMJD2C and Liver
 Stomach Antibodies  >1 publications with JMJD2C and Stomach
 Brain Antibodies  >1 publications with JMJD2C and Brain
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