Rabbit Anti-KLK2 Polyclonal Antibody – Cat# MBS6312001

Western Blot analysis in K562 cell line lysates (35ug/lane) using 037258. KLK2 (arrow) was detected using the purified Pab.

Kallikrein 2 (KLK2) Antibody – Rabbit Polyclonal

Name: KLK2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6312001
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6312001

Kallikreins are a group of serine proteases manifesting diverse physiological functions. The glandular kallikreins are a distinct group of serine proteases with an ability to release vasoactive peptides from kininogen in vitro, although the kininogenase… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Kallikrein 2 (KLK2), Polyclonal Antibody

Full Product Name

Kallikrein 2 (KLK2), CT (KLK2, Kallikrein-2, Glandular kallikrein-1, Tissue kallikrein-2) (MaxLight 550)

Product Gene Name

anti-KLK2 antibody

Product Synonym Names

KLK2; Kallikrein-2; Glandular kallikrein-1; Tissue kallikrein-2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A/G Affinity Chromatography.

Specificity

Recognizes human Kallikrein 2.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

28.5kDa (260aa)

OMIM

147960

3D Structure

ModBase 3D Structure for P20151

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 166-197 in the C-terminal region of human Kallikrein 2, UniProt Accession #P20151

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-KLK2 antibody

Antibodies; Kallikrein

Applications Tested/Suitable for anti-KLK2 antibody

Western Blot (WB), FLISA

Application Notes for anti-KLK2 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-KLK2 antibody

1. Haese, A., et al., J Urol. 2005 Mar;173(3):752-6. 2. Chiang, C.H., et al., J Urol. 2005 Feb;173(2):429-32. 3. Clements, J.A., et al., Crit Rev Clin Lab Sci. 2004;41(3):265-312. 4. Borgono, C.A., et al., Mol Cancer Res. 2004 May;2(5):257-80. 5. Yousef, G.M., Clin Biochem. 2003 Sep;36(6):443-52.

Other Notes

Small volumes of anti-KLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLK2 purchase

MBS6312001 is an antibody targeting KLK2. Also known as Kallikrein 2 (KLK2), CT (KLK2, Kallikrein-2, Glandular kallikrein-1, Tissue kallikrein-2) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK2. It may not necessarily be applicable to this product.

NCBI GI #

5031829

NCBI GeneID

3817

NCBI Accession #

NP_005542

UniProt Primary Accession #

P20151

UniProt Secondary Accession #

Q15946; Q9UJZ9; B4DU93; B4DUB0; F5H8L3

UniProt Related Accession #

P20151

GenBank Nucleotide #

NM_005551.4

NCBI Official Full Name

kallikrein-2 isoform 1 preproprotein

NCBI Official Synonym Full Names

kallikrein related peptidase 2

NCBI Official Symbol

KLK2

NCBI Official Synonym Symbols

hK2; hGK-1; KLK2A2

UniProt Protein Name

Kallikrein-2

UniProt Synonym Protein Names

Glandular kallikrein-1; hGK-1; Tissue kallikrein-2

Protein Family

Blarinasin

UniProt Gene Name

KLK2

UniProt Synonym Gene Names

hGK-1

UniProt Entry Name

KLK2_HUMAN

NCBI Protein Information

kallikrein-2

NCBI Summary for KLK2

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

UniProt Comments for KLK2

KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.35

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis

Research Articles on KLK2

1. glycosylation changes the enzymatic activity of KLK2 in a drastically substrate-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLK2 antibody

Reference Product	PubMed Publications
CARM1 antibody	>1 publications with KLK2 and CARM1
NCOA2 antibody	>1 publications with KLK2 and NCOA2

Pathways associated with anti-KLK2 antibody

Products by Pathway	Pathway Diagram
Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway antibodies	Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies	Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies	Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
RHO GTPase Effectors Pathway antibodies	RHO GTPase Effectors Pathway Diagram
RHO GTPases Activate PKNs Pathway antibodies	RHO GTPases Activate PKNs Pathway Diagram

Diseases associated with anti-KLK2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>71 publications with KLK2 and Neoplasms
Prostatic Neoplasms Antibodies	>60 publications with KLK2 and Prostatic Neoplasms
Breast Neoplasms Antibodies	>10 publications with KLK2 and Breast Neoplasms
Hyperplasia Antibodies	>9 publications with KLK2 and Hyperplasia
Prostatic Hyperplasia Antibodies	>8 publications with KLK2 and Prostatic Hyperplasia
Adenocarcinoma Antibodies	>7 publications with KLK2 and Adenocarcinoma
Ovarian Neoplasms Antibodies	>6 publications with KLK2 and Ovarian Neoplasms
Neoplasms, Experimental Antibodies	>4 publications with KLK2 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with KLK2 and Lung Neoplasms
Neovascularization, Pathologic Antibodies	>2 publications with KLK2 and Neovascularization, Pathologic

Organs/Tissues associated with anti-KLK2 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>99 publications with KLK2 and Prostate
Lung Antibodies	>4 publications with KLK2 and Lung
Testis Antibodies	>3 publications with KLK2 and Testis
Bone Antibodies	>2 publications with KLK2 and Bone
Muscle Antibodies	>1 publications with KLK2 and Muscle
Nerve Antibodies	>1 publications with KLK2 and Nerve