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PAEL Receptor (GPR37) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631201

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease… More details

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Product Overview

Online Datasheet in PDF
Product Name
PAEL Receptor (GPR37), Polyclonal Antibody
Full Product Name
PAEL Receptor, NT (Probable G-protein Coupled Receptor 37, Endothelin B Receptor-like Protein-1, ETBR-LP-1, Parkin-associated Endothelin Receptor-like Receptor, PAELR, GPR37)
Product Gene Name
anti-GPR37 antibody
Product Synonym Names
Anti -PAEL Receptor, NT (Probable G-protein Coupled Receptor 37, Endothelin B Receptor-like Protein-1, ETBR-LP-1, Parkin-associated Endothelin Receptor-like Receptor, PAELR, GPR37)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human Pael-R.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
67,114 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (124385655..124406079, complement). Location: 7q31
OMIM
602583
3D Structure
ModBase 3D Structure for O15354
Immunogen
Synthetic peptide in the N-terminal region of human Pael-R (GPR37) (KLH).

Product Categories/Family for anti-GPR37 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-GPR37 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GPR37 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-GPR37 antibody

Western blot analysis of anti-Pael-R (GPR37) Pab in mouse brain tissue lysate. Pael-R (GPR37) (arrow) was detected using the purified Pab.
Rabbit Anti-GPR37 Polyclonal Antibody – Cat# MBS631201

Immunohistochemistry (IHC) of anti-GPR37 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-GPR37 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS631201

Western Blot (WB) of anti-GPR37 antibody

Pael Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Pael antibody detected the Pael protein (arrow).
Rabbit Anti-GPR37 Polyclonal Antibody, Western Blot (WB) – Cat# MBS631201

Other Notes

Small volumes of anti-GPR37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR37 purchase

MBS631201 is an antibody targeting GPR37. Also known as PAEL Receptor, NT (Probable G-protein Coupled Receptor 37, Endothelin B Receptor-like Protein-1, ETBR-LP-1, Parkin-associated Endothelin Receptor-like Receptor, PAELR, GPR37). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR37. It may not necessarily be applicable to this product.

NCBI GI #
4885323
NCBI GeneID
2861
NCBI Accession #
NP_005293.1
UniProt Primary Accession #
O15354
UniProt Secondary Accession #
O00348; O14768; Q8TD39
UniProt Related Accession #
O15354
GenBank Nucleotide #
NM_005302.3
NCBI Official Full Name
probable G-protein coupled receptor 37
NCBI Official Synonym Full Names
G protein-coupled receptor 37 (endothelin receptor type B-like)
NCBI Official Symbol
GPR37
NCBI Official Synonym Symbols
PAELR; EDNRBL; hET(B)R-LP
UniProt Protein Name
Probable G-protein coupled receptor 37
UniProt Synonym Protein Names
Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor
Protein Family
Prosaposin receptor
UniProt Gene Name
GPR37
UniProt Synonym Gene Names
ETBR-LP-1; PAELR
UniProt Entry Name
GPR37_HUMAN
NCBI Protein Information
probable G-protein coupled receptor 37; ETBR-LP-1; endothelin B receptor-like protein 1; Parkin-associated endothelin receptor-like receptor

NCBI Summary for GPR37

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
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UniProt Comments for GPR37

GPR37: Orphan receptor. May have a unique functional role in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; receptor complex; ubiquitin ligase complex

Molecular Function: G-protein coupled receptor activity; protein binding; heat shock protein binding; ubiquitin protein ligase binding; peptide receptor activity, G-protein coupled; Hsp70 protein binding; peptide binding

Biological Process: positive regulation of dopamine metabolic process; G-protein coupled receptor protein signaling pathway; positive regulation of MAPKKK cascade; G-protein signaling, adenylate cyclase inhibiting pathway; dopamine biosynthetic process; locomotion during locomotory behavior
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Research Articles on GPR37

1. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR37 antibody

 Reference Product  PubMed Publications
 SYVN1 antibody  >3 publications with GPR37 and SYVN1
 PARK2 antibody  >1 publications with GPR37 and PARK2

Pathways associated with anti-GPR37 antibody

 Products by Pathway  Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram

Diseases associated with anti-GPR37 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >18 publications with GPR37 and Brain Diseases
 Nervous System Diseases Antibodies  >18 publications with GPR37 and Nervous System Diseases
 Nerve Degeneration Antibodies  >3 publications with GPR37 and Nerve Degeneration
 Neoplasms Antibodies  >2 publications with GPR37 and Neoplasms
 Disease Models, Animal Antibodies  >2 publications with GPR37 and Disease Models, Animal
 Fibrosis Antibodies  >1 publications with GPR37 and Fibrosis

Organs/Tissues associated with anti-GPR37 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with GPR37 and Brain
 Nerve Antibodies  >16 publications with GPR37 and Nerve
 Embryonic Tissue Antibodies  >2 publications with GPR37 and Embryonic Tissue
 Liver Antibodies  >1 publications with GPR37 and Liver
 Placenta Antibodies  >1 publications with GPR37 and Placenta
 Testis Antibodies  >1 publications with GPR37 and Testis
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