Rabbit Anti-KBTBD10 Polyclonal Antibody – Cat# MBS6312151

Western Blot analysis in NCI-H292 cell line lysates (35ug/lane) usingMBS645349. This demonstrates that MBS645349 detected the KBTBD10 protein (arrow).

KBTBD10 Antibody – Rabbit Polyclonal

Name: KBTBD10 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6312151
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6312151

KBTBD10 is required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KBTBD10, Polyclonal Antibody

Full Product Name

KBTBD10, CT (KBTBD10, KRP1, Kelch repeat and BTB domain-containing protein 10, Kel-like protein 23, Kelch-related protein 1, Sarcosin) (FITC)

Product Gene Name

anti-KBTBD10 antibody

Product Synonym Names

KBTBD10; KRP1; Kelch repeat and BTB domain-containing protein 10; Kel-like protein 23; Kelch-related protein 1; Sarcosin

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human KBTBD10.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

68,037 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (170366212..170382772). Location: 2q31.1

OMIM

607701

3D Structure

ModBase 3D Structure for O60662

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 547-575 in the C-terminal region of human KBTBD10, UniProt Accession #O60662. Species sequence homology: mouse and rat

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-KBTBD10 antibody

Antibodies; Kelch-like Proteins

Applications Tested/Suitable for anti-KBTBD10 antibody

Western Blot (WB), FLISA

Application Notes for anti-KBTBD10 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-KBTBD10 antibody

1. Foster, L.J., et al. J. Proteome Res. 5(1):64-75(2006). 2. Lim, D.S., et al. J. Am. Coll. Cardiol. 38(4):1175-1180(2001). 3. Spence, H.J., et al. Oncogene 19(10):1266-1276(2000). 4. Taylor, A., et al. Mol. Cell. Biochem. 183 (1-2), 105-112 (1998).

Other Notes

Small volumes of anti-KBTBD10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KBTBD10 purchase

MBS6312151 is an antibody targeting KBTBD10. Also known as KBTBD10, CT (KBTBD10, KRP1, Kelch repeat and BTB domain-containing protein 10, Kel-like protein 23, Kelch-related protein 1, Sarcosin) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KBTBD10. It may not necessarily be applicable to this product.

NCBI GI #

42741669

NCBI GeneID

10324

NCBI Accession #

NP_006054.2

UniProt Primary Accession #

O60662

UniProt Secondary Accession #

Q53R42

UniProt Related Accession #

O60662

GenBank Nucleotide #

NM_006063.2

NCBI Official Full Name

kelch-like protein 41

NCBI Official Synonym Full Names

kelch-like family member 41

NCBI Official Symbol

KLHL41

NCBI Official Synonym Symbols

Krp1; KBTBD10; SARCOSIN

UniProt Protein Name

Kelch-like protein 41

UniProt Synonym Protein Names

Kel-like protein 23; Kelch repeat and BTB domain-containing protein 10; Kelch-related protein 1; Sarcosin

UniProt Gene Name

KLHL41

UniProt Synonym Gene Names

KBTBD10; KRP1

UniProt Entry Name

KLH41_HUMAN

NCBI Protein Information

kelch-like protein 41; kelch-like 41; kel-like protein 23; kelch-related protein 1; sarcomeric muscle protein; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10

NCBI Summary for KBTBD10

This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]

UniProt Comments for KBTBD10

KBTBD10: Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Contractile; Cell adhesion; Ubiquitin conjugating system; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: ruffle; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; cytoskeleton; cytoplasm; plasma membrane; M band; pseudopodium; nucleus

Molecular Function: protein binding

Biological Process: myofibril assembly; striated muscle contraction; regulation of myoblast differentiation; protein ubiquitination; regulation of lateral pseudopodium formation

Disease: Nemaline Myopathy 9

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-KBTBD10 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>1 publications with KBTBD10 and Disease Models, Animal
Musculoskeletal Diseases Antibodies	>1 publications with KBTBD10 and Musculoskeletal Diseases
Nervous System Diseases Antibodies	>1 publications with KBTBD10 and Nervous System Diseases

Organs/Tissues associated with anti-KBTBD10 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>3 publications with KBTBD10 and Muscle
Heart Antibodies	>1 publications with KBTBD10 and Heart