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HGS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631272

HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via… More details

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Product Overview

Online Datasheet in PDF
Product Name
HGS, Polyclonal Antibody
Full Product Name
HGS, NT (HRS, Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate, HGNC:4897, Human Growth Factor Regulated Tyrosine Kinase Substrate, Protein pp110, ZFYVE8)
Product Gene Name
Product Synonym Names
Anti -HGS, NT (HRS, Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate, HGNC:4897, Human Growth Factor Regulated Tyrosine Kinase Substrate, Protein pp110, ZFYVE8)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human HGS. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
86,015 Da
Chromosome Location
Chromosome: 11; NC_000077.6 (120467635..120483984). Location: 11 E2; 11 84.16 cM
3D Structure
ModBase 3D Structure for Q99LI8
Immunogen
Synthetic peptide selected from the N-terminal region of human HGS (KLH).
Applications Tested/Suitable for anti-Hgs antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Hgs antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-Hgs antibody

Western blot analysis of hIMOS-1-Q271 in mouse spleen tissue lysates (35ug/lane). IMOS-1 (arrow) was detected using the purified Pab.
Rabbit Anti-HGS Polyclonal Antibody – Cat# MBS631272

Immunohistochemistry (IHC) of anti-Hgs antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-HGS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS631272

Other Notes

Small volumes of anti-Hgs antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hgs purchase

MBS631272 is an antibody targeting Hgs. Also known as HGS, NT (HRS, Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate, HGNC:4897, Human Growth Factor Regulated Tyrosine Kinase Substrate, Protein pp110, ZFYVE8). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Hgs. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2
NCBI Official Synonym Full Names
HGF-regulated tyrosine kinase substrate
NCBI Official Symbol
Hgs
NCBI Official Synonym Symbols
Hgr; Hrs; ZFYVE8
UniProt Protein Name
Hepatocyte growth factor-regulated tyrosine kinase substrate
UniProt Gene Name
Hgs
UniProt Synonym Gene Names
Hrs
UniProt Entry Name
HGS_MOUSE
NCBI Protein Information
hepatocyte growth factor-regulated tyrosine kinase substrate

UniProt Comments for Hgs

Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Cellular Component: membrane; intracellular membrane-bound organelle; early endosome; cytoplasm; cytosol; endosome; secretory granule

Molecular Function: protein domain specific binding; metal ion binding

Biological Process: intracellular protein transport; protein transport; protein targeting to lysosome; transport; membrane invagination; endosome to lysosome transport; negative regulation of JAK-STAT cascade
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Hgs antibody

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