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KCNV2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6312786

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCNV2, Polyclonal Antibody
Full Product Name
KCNV2, CT (KCNV2, Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv8.2) (AP)
Product Gene Name
anti-KCNV2 antibody
Product Synonym Names
KCNV2; Potassium voltage-gated channel subfamily V member 2; Voltage-gated potassium channel subunit Kv8.2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
62,459 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (2717526..2730037). Location: 9p24.2
OMIM
607604
3D Structure
ModBase 3D Structure for Q8TDN2
Immunogen
KCNV2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-507 amino acids from the C-terminal region of human KCNV2.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-KCNV2 antibody

Antibodies; Ion Channel
Applications Tested/Suitable for anti-KCNV2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-KCNV2 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-KCNV2 antibody

KCNV2 Antibody (C-term) western blot analysis in 293,K562,HepG2,Jurkat,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the KCNV2 antibody detected the KCNV2 protein (arrow).
Rabbit Anti-KCNV2 Polyclonal Antibody – Cat# MBS6312786

Immunohistochemistry (IHC) of anti-KCNV2 antibody

KCNV2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNV2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-KCNV2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6312786

Product References and Citations for anti-KCNV2 antibody

Robson, A.G., et al. Retina (Philadelphia, Pa.) 30(1):51-62(2010). Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008). Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008). Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007). Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007).

Other Notes

Small volumes of anti-KCNV2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNV2 purchase

MBS6312786 is an antibody targeting KCNV2. Also known as KCNV2, CT (KCNV2, Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv8.2) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNV2. It may not necessarily be applicable to this product.

NCBI GI #
19424136
NCBI GeneID
169522
NCBI Accession #
NP_598004.1
UniProt Primary Accession #
Q8TDN2
UniProt Secondary Accession #
Q5T6X0
UniProt Related Accession #
Q8TDN2
GenBank Nucleotide #
NM_133497.3
NCBI Official Full Name
potassium voltage-gated channel subfamily V member 2
NCBI Official Synonym Full Names
potassium channel, subfamily V, member 2
NCBI Official Symbol
KCNV2
NCBI Official Synonym Symbols
Kv8.2; RCD3B; KV11.1
UniProt Protein Name
Potassium voltage-gated channel subfamily V member 2
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv8.2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNV2
UniProt Entry Name
KCNV2_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily V member 2; voltage-gated potassium channel subunit Kv8.2

UniProt Comments for KCNV2

Kv8.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Defects in KCNV2 are the cause of cone dystrophy retinal type 3B (RCD3B); also called cone dystrophy with night blindness and supernormal rod responses KCNV2-related. RCD3B is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p24.2

Cellular Component: voltage-gated potassium channel complex; plasma membrane; integral to membrane

Molecular Function: delayed rectifier potassium channel activity

Biological Process: synaptic transmission; protein homooligomerization

Disease: Retinal Cone Dystrophy 3b
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Research Articles on KCNV2

1. Central vision parameters progressively worsen in KCNV2 cone dystrophy, structural retinal and lipofuscin accumulation abnormalities are commonly present and macular cone photoreceptor mosaic is markedly disrupted early in the disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNV2 antibody

 Reference Product  PubMed Publications
 KCNB1 antibody  >4 publications with KCNV2 and KCNB1
 KCNF1 antibody  >1 publications with KCNV2 and KCNF1

Pathways associated with anti-KCNV2 antibody

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNV2 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >7 publications with KCNV2 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >5 publications with KCNV2 and Heart Defects, Congenital
 Retinal Cone Dystrophy 3B Antibodies  >2 publications with KCNV2 and Retinal Cone Dystrophy 3B
 Seizures Antibodies  >1 publications with KCNV2 and Seizures
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