P2X3 Receptor (P2RX3) Antibody – Rabbit Polyclonal

Purinergic receptor P2X, ligand-gated ion channel, 3, also known as P2X3, is a human gene. Its gene is mapped to 11q12. P2X purinoceptors are 397 to 492aa long and have a predicted structure of 2 short intracellular domains, 2 transmembrane-spanning regions, and a large extracellular domain.The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2, respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved.1 P2X3 was the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel, coupled with a sensory neuron-like pharmacology,suggested that it may transduce ATP-evoked nociceptor activation. If ATP, and more specifically, P2X3 purinoceptors are involved in nociception, then the development of an antagonist selective for P2X3 could prove useful in pain relief. Lack of P2X3 in other tissues than sensory ganglia could afford a degree of specificity, leading to fewer side effects.

Small volumes of anti-P2RX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS631279 is an antibody targeting P2RX3. Also known as P2X3 Receptor (P2X Purinoceptor 3, P2X3, ATP Receptor, Purinergic Receptor, P2RX3). Reactive in Human, Mouse, Rat. Host: Rabbit.