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KIF2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6313276

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KIF2C, Polyclonal Antibody
Full Product Name
KIF2C, NT (KIF2C, KNSL6, Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin) (MaxLight 490)
Product Gene Name
anti-KIF2C antibody
Product Synonym Names
KIF2C; KNSL6; Kinesin-like protein KIF2C; Kinesin-like protein 6; Mitotic centromere-associated kinesin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
81,313 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (45205490..45233439). Location: 1p34.1
OMIM
604538
3D Structure
ModBase 3D Structure for Q99661
Immunogen
KIF2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-208 amino acids from the N-terminal region of human KIF2C.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-KIF2C antibody

Antibodies; Centromeres
Applications Tested/Suitable for anti-KIF2C antibody
Western Blot (WB), FLISA
Application Notes for anti-KIF2C antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-KIF2C antibody

Tanno, Y., et al. Genes Dev. 24(19):2169-2179(2010). Gnjatic, S., et al. Int. J. Cancer 127(2):381-393(2010). Sanhaji, M., et al. Mol. Cell. Biol. 30(11):2594-2607(2010). Olson, J.E., et al. Breast Cancer Res. Treat. (2010). In press: Kollu, S., et al. Curr. Biol. 19(24):2108-2113(2009).

Other Notes

Small volumes of anti-KIF2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIF2C purchase

MBS6313276 is an antibody targeting KIF2C. Also known as KIF2C, NT (KIF2C, KNSL6, Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin) (MaxLight 490). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KIF2C. It may not necessarily be applicable to this product.

NCBI GI #
166795250
NCBI GeneID
11004
NCBI Accession #
NP_006836.2
UniProt Primary Accession #
Q99661
UniProt Secondary Accession #
Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q9BWV8; B3ITR9
UniProt Related Accession #
Q99661
GenBank Nucleotide #
NM_006845.3
NCBI Official Full Name
kinesin-like protein KIF2C
NCBI Official Synonym Full Names
kinesin family member 2C
NCBI Official Symbol
KIF2C
NCBI Official Synonym Symbols
MCAK; KNSL6
UniProt Protein Name
Kinesin-like protein KIF2C
UniProt Synonym Protein Names
Kinesin-like protein 6; Mitotic centromere-associated kinesin
Protein Family
Kinesin-like protein
UniProt Gene Name
KIF2C
UniProt Synonym Gene Names
KNSL6; MCAK
UniProt Entry Name
KIF2C_HUMAN
NCBI Protein Information
kinesin-like protein KIF2C; kinesin-like 6; kinesin-like protein 6; mitotic centromere-associated kinesin

UniProt Comments for KIF2C

KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: kinetochore; microtubule cytoskeleton; kinesin complex; membrane; cytoplasmic microtubule; cytosol; nucleus; chromosome, pericentric region

Molecular Function: centromeric DNA binding; microtubule plus-end binding; protein binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: mitosis; cell proliferation; cell division; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule depolymerization; regulation of chromosome segregation; mitotic cell cycle; blood coagulation; mitotic metaphase plate congression; microtubule-based movement; establishment and/or maintenance of microtubule cytoskeleton polarity
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Research Articles on KIF2C

1. PAK1 phosphorylates MCAK and regulates both its localization and function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KIF2C antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Kinesins Pathway antibodies  Kinesins Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram

Diseases associated with anti-KIF2C antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >17 publications with KIF2C and Neoplasms
 Carcinoma Antibodies  >4 publications with KIF2C and Carcinoma
 Breast Neoplasms Antibodies  >4 publications with KIF2C and Breast Neoplasms
 Brain Diseases Antibodies  >2 publications with KIF2C and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with KIF2C and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with KIF2C and Adenocarcinoma
 Atherosclerosis Antibodies  >1 publications with KIF2C and Atherosclerosis
 Prostatic Neoplasms Antibodies  >1 publications with KIF2C and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >1 publications with KIF2C and Liver Neoplasms

Organs/Tissues associated with anti-KIF2C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with KIF2C and Blood
 Testis Antibodies  >4 publications with KIF2C and Testis
 Lymph Antibodies  >2 publications with KIF2C and Lymph
 Intestine Antibodies  >2 publications with KIF2C and Intestine
 Lymph Node Antibodies  >2 publications with KIF2C and Lymph Node
 Brain Antibodies  >2 publications with KIF2C and Brain
 Stomach Antibodies  >1 publications with KIF2C and Stomach
 Muscle Antibodies  >1 publications with KIF2C and Muscle
 Liver Antibodies  >1 publications with KIF2C and Liver
 Thymus Antibodies  >1 publications with KIF2C and Thymus
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