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HDAC11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631386

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle… More details

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Product Overview

Online Datasheet in PDF
Product Name
HDAC11, Polyclonal Antibody
Full Product Name
HDAC11, NT (Histone Deacetylase 11, HD11)
Product Gene Name
anti-HDAC11 antibody
Product Synonym Names
Anti -HDAC11, NT (Histone Deacetylase 11, HD11)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human HDAC11. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,183 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (13521715..13547924). Location: 3p25.1
OMIM
607226
3D Structure
ModBase 3D Structure for Q96DB2
Immunogen
Synthetic peptide selected from the N-terminal region of human HDAC11 (KLH).

Product Categories/Family for anti-HDAC11 antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-HDAC11 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HDAC11 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-HDAC11 antibody

Western blot analysis of anti-HDAC11 Pab in mouse brain tissue lysate. HDAC11 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-HDAC11 Polyclonal Antibody – Cat# MBS631386

Western Blot (WB) of anti-HDAC11 antibody

Western blot analysis of HDAC11 (arrow) using HDAC11 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HDAC11 gene (Lane 2).
Rabbit Anti-HDAC11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS631386

Immunohistochemistry (IHC) of anti-HDAC11 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-HDAC11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS631386

Western Blot (WB) of anti-HDAC11 antibody

HDAC11 Antibody (M1) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the HDAC11 antibody detected the HDAC11 protein (arrow).
Rabbit Anti-HDAC11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS631386

Other Notes

Small volumes of anti-HDAC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC11 purchase

MBS631386 is an antibody targeting HDAC11. Also known as HDAC11, NT (Histone Deacetylase 11, HD11). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC11. It may not necessarily be applicable to this product.

NCBI GI #
217272877
NCBI GeneID
79885
NCBI Accession #
NP_079103.2
UniProt Primary Accession #
Q96DB2
UniProt Secondary Accession #
Q9H6I7; Q9H6X3; Q9NTC9
UniProt Related Accession #
Q658J9; Q6IA14; Q96DB2
GenBank Nucleotide #
NM_024827.3
NCBI Official Full Name
histone deacetylase 11 isoform 1
NCBI Official Synonym Full Names
histone deacetylase 11
NCBI Official Symbol
HDAC11
NCBI Official Synonym Symbols
HD11; FLJ22237
UniProt Protein Name
Histone deacetylase 11
Protein Family
Histone deacetylase
UniProt Gene Name
HDAC11
UniProt Entry Name
HDA11_HUMAN
NCBI Protein Information
histone deacetylase 11; OTTHUMP00000160231; OTTHUMP00000197639; OTTHUMP00000197644; OTTHUMP00000197649; OTTHUMP00000208001; OTTHUMP00000209466; OTTHUMP00000226982

NCBI Summary for HDAC11

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

UniProt Comments for HDAC11

HDAC11: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.98; Deacetylase

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: histone deacetylase complex; plasma membrane; nucleus

Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone deacetylation; chromatin modification; oligodendrocyte development
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Research Articles on HDAC11

1. These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HDAC11 antibody

 Reference Product  PubMed Publications
 HDAC6 antibody  >7 publications with HDAC11 and HDAC6

Pathways associated with anti-HDAC11 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Signaling Events Mediated By HDAC Class II Pathway antibodies  Signaling Events Mediated By HDAC Class II Pathway Diagram

Diseases associated with anti-HDAC11 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with HDAC11 and Neoplasms
 Inflammation Antibodies  >4 publications with HDAC11 and Inflammation
 Drug Toxicity Antibodies  >2 publications with HDAC11 and Drug Toxicity
 Carcinoma Antibodies  >2 publications with HDAC11 and Carcinoma
 Medulloblastoma Antibodies  >1 publications with HDAC11 and Medulloblastoma
 Leukemia Antibodies  >1 publications with HDAC11 and Leukemia
 Congenital Abnormalities Antibodies  >1 publications with HDAC11 and Congenital Abnormalities
 Leukemia, Myeloid Antibodies  >1 publications with HDAC11 and Leukemia, Myeloid
 Intestinal Diseases Antibodies  >1 publications with HDAC11 and Intestinal Diseases
 Gonadal Disorders Antibodies  >1 publications with HDAC11 and Gonadal Disorders

Organs/Tissues associated with anti-HDAC11 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with HDAC11 and Liver
 Thyroid Antibodies  >1 publications with HDAC11 and Thyroid
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