Rabbit Anti-LAT2 Polyclonal Antibody – Cat# MBS6315284

LAT2 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the LAT2 antibody detected the LAT2 protein (arrow).

LAT2 Antibody – Rabbit Polyclonal

Name: LAT2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6315284
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6315284

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LAT2, Polyclonal Antibody

Full Product Name

LAT2, ID (LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5, Linker for activation of T-cells family member 2, Linker for activation of B Cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 prote

Product Gene Name

anti-LAT2 antibody

Product Synonym Names

LAT2; LAB; NTAL; WBS15; WBSCR15; WBSCR5; Linker for activation of T-cells family member 2; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

12,255 Da

OMIM

605719

3D Structure

ModBase 3D Structure for Q9GZY6

Immunogen

LAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human LAT2.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-LAT2 antibody

Antibodies; Adapter Proteins

Applications Tested/Suitable for anti-LAT2 antibody

Western Blot (WB), FLISA

Application Notes for anti-LAT2 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-LAT2 antibody

Rieke, C., et al. Cell. Signal. 22(3):395-403(2010). Luo, X., et al. J. Clin. Endocrinol. Metab. 94(11):4533-4539(2009). Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009). Svojgr, K., et al. Immunol. Lett. 122(2):185-192(2009). Whittaker, G.C., et al. Blood 112(7):2869-2877(2008).

Other Notes

Small volumes of anti-LAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAT2 purchase

MBS6315284 is an antibody targeting LAT2. Also known as LAT2, ID (LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5, Linker for activation of T-cells family member 2, Linker for activation of B Cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 prote. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LAT2. It may not necessarily be applicable to this product.

NCBI GI #

14702182

NCBI GeneID

7462

NCBI Accession #

NP_054865.2

NCBI Related Accession #

NP_115852.1

UniProt Primary Accession #

Q9GZY6

UniProt Secondary Accession #

Q9BXX8; Q9NZY9; A6NFK6; A8K209; A8K4F1; D3DXF9

UniProt Related Accession #

Q9GZY6

GenBank Nucleotide #

NM_014146.3

NCBI Official Full Name

linker for activation of T-cells family member 2

NCBI Official Synonym Full Names

linker for activation of T cells family, member 2

NCBI Official Symbol

LAT2

NCBI Official Synonym Symbols

LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15

UniProt Protein Name

Linker for activation of T-cells family member 2

UniProt Synonym Protein Names

Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein

Protein Family

Linker for activation of T-cells family

UniProt Gene Name

LAT2

UniProt Synonym Gene Names

LAB; NTAL; WBS15; WBSCR15; WBSCR5

UniProt Entry Name

NTAL_HUMAN

NCBI Protein Information

linker for activation of T-cells family member 2; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; linker for activation of B-cells; linker for activation of T cells, transmembrane adaptor 2; m

UniProt Comments for LAT2

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation

Research Articles on LAT2

1. The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LAT2 antibody

Reference Product	PubMed Publications
LAT antibody	>49 publications with LAT2 and LAT
GRB2 antibody	>14 publications with LAT2 and GRB2
CBL antibody	>4 publications with LAT2 and CBL
GAB1 antibody	>2 publications with LAT2 and GAB1
BLNK antibody	>1 publications with LAT2 and BLNK
SOS1 antibody	>1 publications with LAT2 and SOS1

Pathways associated with anti-LAT2 antibody

Products by Pathway	Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies	Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies	Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway antibodies	Role Of LAT2/NTAL/LAB On Calcium Mobilization Pathway Diagram

Diseases associated with anti-LAT2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>8 publications with LAT2 and Inflammation
Liver Diseases Antibodies	>7 publications with LAT2 and Liver Diseases
Disease Models, Animal Antibodies	>7 publications with LAT2 and Disease Models, Animal
Kidney Diseases Antibodies	>5 publications with LAT2 and Kidney Diseases
Brain Diseases Antibodies	>5 publications with LAT2 and Brain Diseases
Necrosis Antibodies	>5 publications with LAT2 and Necrosis
Carcinoma, Hepatocellular Antibodies	>3 publications with LAT2 and Carcinoma, Hepatocellular
Death Antibodies	>3 publications with LAT2 and Death
Liver Neoplasms Antibodies	>3 publications with LAT2 and Liver Neoplasms
Edema Antibodies	>2 publications with LAT2 and Edema

Organs/Tissues associated with anti-LAT2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>57 publications with LAT2 and Blood
Brain Antibodies	>45 publications with LAT2 and Brain
Kidney Antibodies	>33 publications with LAT2 and Kidney
Intestine Antibodies	>29 publications with LAT2 and Intestine
Muscle Antibodies	>14 publications with LAT2 and Muscle
Placenta Antibodies	>13 publications with LAT2 and Placenta
Liver Antibodies	>13 publications with LAT2 and Liver
Eye Antibodies	>9 publications with LAT2 and Eye
Spleen Antibodies	>5 publications with LAT2 and Spleen
Lung Antibodies	>5 publications with LAT2 and Lung