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Nkp46, Natural Cytotoxicity Receptor (NCR1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631529

CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is expressed by human natural killer cells (Sivori et al. 1997). The bovine homologue is expressed on bovine… More details

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Product Overview

Online Datasheet in PDF
Product Name
NKp46, Natural Cytotoxicity Receptor (NCR1), Monoclonal Antibody
Full Product Name
NKp46, Natural Cytotoxicity Receptor (NCR NKp46, CD335, Lymphocyte Antigen 94, Ly94, Natural Cytotoxicity Triggering Receptor 1, NCR1, NCT1, Natural Killer Cell Activating Receptor NKp46, NK Cell Activating Receptor) (PE)
Product Gene Name
Product Synonym Names
Anti -NKp46, Natural Cytotoxicity Receptor (NCR NKp46, CD335, Lymphocyte Antigen 94, Ly94, Natural Cytotoxicity Triggering Receptor 1, NCR1, NCT1, Natural Killer Cell Activating Receptor NKp46, NK Cell Activating Receptor) (PE)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10B1431 (AKS1)
Host
Mouse
Species Reactivity
Bovine, American Bison
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.4, 1% BSA, 0.09% sodium azide, 5% sucrose. Labeled with R-Phycoerythrin (PE).
Reconstitute with 1ml sterile ddH2O.
Purity/Purification
Purified by Protein G affinity chromatography from tissue culture supernatant
Specificity
Recognizes bovine CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1.
Preparation and Storage
Store product at 4°C before and after reconstitution. DO NOT FREEZE! Lyophilized and reconstituted products are stable for 12 months at 4°C after receipt. Reconstitute lyophilized powder with sterile ddH2O prior to use and store remainder as an undiluted liquid.

Caution: PE conjugates are sensitive to light. For maximum recovery of product centrifuge the original vial prior to removing the cap.
Chromosome Location
Chromosome: 19; NC_000019.9 (55417504..55424454). Location: 19q13.42
OMIM
604530
3D Structure
ModBase 3D Structure for O76036
Grade
Affinity Purified
Immunogen
Fusion protein consisting of the extracellular region of bovine CD335.

Product Categories/Family for anti-NCR1 antibody

Applications Tested/Suitable for anti-NCR1 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-NCR1 antibody
Recommended Dilutions: Flow Cytometry: Neat. 10ul labels 10e6 cells in 100ul.

Other applications not tested. Optimal dilutions to be determined by the researcher.

Flow Cytometry (FC/FACS) of anti-NCR1 antibody

Staining of bovine peripheral blood lymphocytes with MBS631529. A small positive peak representing NK cells can be identified.
Mouse Anti-NCR1 Monoclonal Antibody – Cat# MBS631529

Other Notes

Small volumes of anti-NCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCR1 purchase

MBS631529 is an antibody targeting NCR1. Also known as NKp46, Natural Cytotoxicity Receptor (NCR NKp46, CD335, Lymphocyte Antigen 94, Ly94, Natural Cytotoxicity Triggering Receptor 1, NCR1, NCT1, Natural Killer Cell Activating Receptor NKp46, NK Cell Activating Receptor) (PE). Reactive in Bovine, American Bison. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NCR1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
natural cytotoxicity triggering receptor 1 isoform a
NCBI Official Synonym Full Names
natural cytotoxicity triggering receptor 1
NCBI Official Symbol
NCR1
NCBI Official Synonym Symbols
LY94; CD335; NKP46; NK-p46
UniProt Protein Name
Natural cytotoxicity triggering receptor 1
UniProt Synonym Protein Names
Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein
UniProt Gene Name
NCR1
UniProt Synonym Gene Names
LY94; NK-p46; NKp46; hNKp46
UniProt Entry Name
NCTR1_HUMAN
NCBI Protein Information
natural cytotoxicity triggering receptor 1; NK cell-activating receptor; natural killer cell p46-related protein; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46)

UniProt Comments for NCR1

NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: SWI/SNF complex; integral to plasma membrane

Molecular Function: receptor signaling protein activity

Biological Process: regulation of natural killer cell mediated cytotoxicity; natural killer cell activation; cellular defense response; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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