Rabbit Anti-LIN9 Polyclonal Antibody – Cat# MBS6316306

LIN9 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the LIN9 antibody detected the LIN9 protein (arrow).

LIN9 Antibody – Rabbit Polyclonal

Name: LIN9 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6316306
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6316306

LIN9 acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LIN9, Polyclonal Antibody

Full Product Name

LIN9, NT (LIN9, BARA, TGS, Protein lin-9 homolog, Beta subunit-associated regulator of apoptosis, TUDOR gene similar protein, Type I interferon receptor beta chain-associated protein, pRB-associated protein) (AP)

Product Gene Name

anti-LIN9 antibody

Product Synonym Names

LIN9; BARA; TGS; Protein lin-9 homolog; Beta subunit-associated regulator of apoptosis; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; pRB-associated protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

609375

3D Structure

ModBase 3D Structure for Q5TKA1

Immunogen

LIN9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human LIN9.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-LIN9 antibody

Antibodies; Apoptosis

Applications Tested/Suitable for anti-LIN9 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-LIN9 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-LIN9 antibody

Rose, J. Phd, et al. Mol. Med. (2010). In press: Arking, D.E., et al. PLoS ONE 5 (3), E9879 (2010): Pilkinton, M., et al. Oncogene 26(54):7535-7543(2007). Osterloh, L., et al. EMBO J. 26(1):144-157(2007). Pilkinton, M., et al. J. Biol. Chem. 282(1):168-175(2007).

Other Notes

Small volumes of anti-LIN9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LIN9 purchase

MBS6316306 is an antibody targeting LIN9. Also known as LIN9, NT (LIN9, BARA, TGS, Protein lin-9 homolog, Beta subunit-associated regulator of apoptosis, TUDOR gene similar protein, Type I interferon receptor beta chain-associated protein, pRB-associated protein) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LIN9. It may not necessarily be applicable to this product.

NCBI GI #

32996737

NCBI GeneID

286826

NCBI Accession #

NP_775106.2

UniProt Primary Accession #

Q5TKA1

UniProt Related Accession #

Q5TKA1

GenBank Nucleotide #

NP_775106.2

NCBI Official Full Name

protein lin-9 homolog isoform 1

NCBI Official Synonym Full Names

lin-9 DREAM MuvB core complex component

NCBI Official Symbol

LIN9

NCBI Official Synonym Symbols

TGS; BARA; TGS1; TGS2; Lin-9; BARPsv

UniProt Protein Name

Protein lin-9 homolog

UniProt Synonym Protein Names

Beta subunit-associated regulator of apoptosis; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein; pRB-associated protein

Protein Family

Protein

UniProt Gene Name

LIN9

UniProt Synonym Gene Names

BARA; TGS; HuLin-9; hLin-9

UniProt Entry Name

LIN9_HUMAN

NCBI Protein Information

protein lin-9 homolog

NCBI Summary for LIN9

This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

UniProt Comments for LIN9

LIN9: a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. Component of the DREAM complex composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBBP4, RBL2, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RB1. Three alternative spliced human isoforms have been reported.

Protein type: Cell cycle regulation; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q42.12

Cellular Component: nucleoplasm; transcriptional repressor complex

Molecular Function: protein binding

Biological Process: transcription, DNA-dependent; regulation of cell cycle; mitotic cell cycle; G2/M transition of mitotic cell cycle

Research Articles on LIN9

1. High LIN9 expression is associated with Triple-negative breast cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.