Mouse Anti-NLRP2 Monoclonal Antibody – Cat# MBS631648

Detection of NALP2: Lysates from human A549 and LNCaP cells were resolved by SDS-PAGE, transferred to Immobilon membranes and immunoblotted with 1ug/ml MBS631648.

NLRP2 Antibody – Mouse Monoclonal

Name: NLRP2 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS631648
Price: 1045 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631648

NALP2 (NAcht Leucine-rich repeat Protein 2, also known as PAN1) is a cytosolic, 121kD member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NFkB, it suppresses TNF-alpha production in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NALP2 (NLRP2), Monoclonal Antibody

Full Product Name

NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, Nucleotide-binding Site Protein 1, PYRIN Domain and NACHT Domain-containing Protein 1, PYRIN-containing APAF1-like Protein 2, NLRP2, NBS1, PAN1, PYPAF2)

Product Gene Name

anti-NLRP2 antibody

Product Synonym Names

Anti -NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, Nucleotide-binding Site Protein 1, PYRIN Domain and NACHT Domain-containing Protein 1, PYRIN-containing APAF1-like Protein 2, NLRP2, NBS1, PAN1, PYPAF2)

Clonality

Monoclonal

Isotype

IgG2A

Clone Number

11C41

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute in 100uL of PBS, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human NALP2.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

22,291 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (55476652..55512510). Location: 19q13.42

3D Structure

ModBase 3D Structure for Q8WY49

Immunogen

Purified, E. coli-derived recombinant human NALP2 (rhNALP2; aa1-208; Accession # Q9NX02).

Product Categories/Family for anti-NLRP2 antibody

Antibodies; Abs to Apoptosis

Applications Tested/Suitable for anti-NLRP2 antibody

Western Blot (WB)

Application Notes for anti-NLRP2 antibody

Suitable for use in Western Blot.
Dilution: Western Blot: 1ug/ml

Other Notes

Small volumes of anti-NLRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP2 purchase

MBS631648 is an antibody targeting NLRP2. Also known as NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, Nucleotide-binding Site Protein 1, PYRIN Domain and NACHT Domain-containing Protein 1, PYRIN-containing APAF1-like Protein 2, NLRP2, NBS1, PAN1, PYPAF2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP2. It may not necessarily be applicable to this product.

NCBI GI #

291463280

NCBI GeneID

55655

NCBI Accession #

NP_001167554.1

UniProt Primary Accession #

Q8WY49

UniProt Related Accession #

Q8WY49; Q9NX02

GenBank Nucleotide #

NM_001174083.1

NCBI Official Full Name

NACHT, LRR and PYD domains-containing protein 2 isoform 3

NCBI Official Synonym Full Names

NLR family, pyrin domain containing 2

NCBI Official Symbol

NLRP2

NCBI Official Synonym Symbols

NBS1; PAN1; NALP2; PYPAF2; CLR19.9; FLJ20510

UniProt Protein Name

NACHT, leucine rich repeat and PYD containing 2, isoform CRA_c

Protein Family

NACHT, LRR and PYD domains-containing protein

UniProt Gene Name

PP1579

UniProt Synonym Gene Names

NALP2

UniProt Entry Name

Q8WY49_HUMAN

NCBI Protein Information

NACHT, LRR and PYD domains-containing protein 2; OTTHUMP00000236775; OTTHUMP00000236776; OTTHUMP00000236777; OTTHUMP00000236779; OTTHUMP00000236780; nucleotide-binding site protein 1; PYRIN-containing APAF1-like protein 2; NACHT, LRR and PYD containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2

NCBI Summary for NLRP2

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]

UniProt Comments for NLRP2

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm

Molecular Function: protein binding; Pyrin domain binding; ATP binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion

Research Articles on NLRP2

1. Our observations are the first to implicate SPARC, SLPI, and NLRP2, a component of the innate immune system, in the pathogenesis of axial spondyloarthropathy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLRP2 antibody

Reference Product	PubMed Publications
CARD8 antibody	>2 publications with NLRP2 and CARD8

Diseases associated with anti-NLRP2 antibody

Disease Name	Pubmed Publications
Arthritis, Rheumatoid Antibodies	>1 publications with NLRP2 and Arthritis, Rheumatoid
Pregnancy Complications Antibodies	>1 publications with NLRP2 and Pregnancy Complications

Organs/Tissues associated with anti-NLRP2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with NLRP2 and Blood
Brain Antibodies	>3 publications with NLRP2 and Brain
Kidney Antibodies	>2 publications with NLRP2 and Kidney
Embryonic Tissue Antibodies	>2 publications with NLRP2 and Embryonic Tissue
Intestine Antibodies	>1 publications with NLRP2 and Intestine
Eye Antibodies	>1 publications with NLRP2 and Eye
Ovary Antibodies	>1 publications with NLRP2 and Ovary
Heart Antibodies	>1 publications with NLRP2 and Heart
Skin Antibodies	>1 publications with NLRP2 and Skin
Pancreas Antibodies	>1 publications with NLRP2 and Pancreas