Rabbit Anti-MAK Polyclonal Antibody – Cat# MBS6318120

MAK Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MAK antibody detected the MAK protein (arrow).

MAK Antibody – Rabbit Polyclonal

Name: MAK Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6318120
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6318120

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAK, Polyclonal Antibody

Full Product Name

MAK, CT (MAK, Serine/threonine-protein kinase MAK, Male germ cell-associated kinase) (PE)

Product Gene Name

anti-MAK antibody

Product Synonym Names

MAK; Serine/threonine-protein kinase MAK; Male germ cell-associated kinase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

66,345 Da

OMIM

154235

3D Structure

ModBase 3D Structure for P20794

Immunogen

MAK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 595-623 amino acids from the C-terminal region of human MAK.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-MAK antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-MAK antibody

Western Blot (WB), FLISA

Application Notes for anti-MAK antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MAK antibody

Fu, Z., et al. Mol. Cell. Biol. 26(22):8639-8654(2006). Ma, A.H., et al. Cancer Res. 66(17):8439-8447(2006). Mungall, A.J., et al. Nature 425(6960):805-811(2003). Xia, L., et al. J. Biol. Chem. 277(38):35422-35433(2002). Taketo, M., et al. Genomics 19(2):397-398(1994).

Other Notes

Small volumes of anti-MAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAK purchase

MBS6318120 is an antibody targeting MAK. Also known as MAK, CT (MAK, Serine/threonine-protein kinase MAK, Male germ cell-associated kinase) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAK. It may not necessarily be applicable to this product.

NCBI GI #

11496279

NCBI GeneID

4117

NCBI Accession #

NP_005897.1

UniProt Primary Accession #

P20794

UniProt Secondary Accession #

Q547D0; Q9NUH7; F1T0K6; G1FL29

UniProt Related Accession #

P20794

GenBank Nucleotide #

NM_005906.5

NCBI Official Full Name

serine/threonine-protein kinase MAK isoform 1

NCBI Official Synonym Full Names

male germ cell associated kinase

NCBI Official Symbol

MAK

NCBI Official Synonym Symbols

RP62

UniProt Protein Name

Serine/threonine-protein kinase MAK

UniProt Synonym Protein Names

Male germ cell-associated kinase

Protein Family

Maltokinase

UniProt Gene Name

MAK

UniProt Entry Name

MAK_HUMAN

NCBI Protein Information

serine/threonine-protein kinase MAK

NCBI Summary for MAK

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

UniProt Comments for MAK

MAK: a protein kinase of the RCK family of kinases. It is expressed at high levels in the testis (primarily in germ cells), and in developing sensory epithelia. Localizes to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.22; Nuclear receptor co-regulator; Protein kinase, CMGC; CMGC group; RCK family

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: centrosome; photoreceptor outer segment; photoreceptor inner segment; cytoplasm; midbody; nucleus

Molecular Function: protein binding; cyclin-dependent protein kinase activity; transcription coactivator activity; ATP binding; protein kinase activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of cell cycle; multicellular organismal development; protein amino acid autophosphorylation; photoreceptor cell maintenance; spermatogenesis; cell differentiation; protein amino acid phosphorylation

Disease: Retinitis Pigmentosa 62

Research Articles on MAK

1. One patient was homozygous for the insertion, one compound heterozygous with a missense change on the other allele (c. 46G>A; p.Gly16Arg), and three were heterozygous carriers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAK antibody

Reference Product	PubMed Publications
FZR1 antibody	>1 publications with MAK and FZR1

Pathways associated with anti-MAK antibody

Products by Pathway	Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with anti-MAK antibody

Disease Name	Pubmed Publications
Vascular Diseases Antibodies	>359 publications with MAK and Vascular Diseases
Heart Diseases Antibodies	>295 publications with MAK and Heart Diseases
Inflammation Antibodies	>258 publications with MAK and Inflammation
Lung Diseases Antibodies	>244 publications with MAK and Lung Diseases
Necrosis Antibodies	>216 publications with MAK and Necrosis
Kidney Diseases Antibodies	>207 publications with MAK and Kidney Diseases
Hypertension Antibodies	>109 publications with MAK and Hypertension
Lung Neoplasms Antibodies	>98 publications with MAK and Lung Neoplasms
Adenocarcinoma Antibodies	>96 publications with MAK and Adenocarcinoma
Fibrosis Antibodies	>81 publications with MAK and Fibrosis

Organs/Tissues associated with anti-MAK antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1375 publications with MAK and Blood
Brain Antibodies	>409 publications with MAK and Brain
Muscle Antibodies	>350 publications with MAK and Muscle
Lung Antibodies	>303 publications with MAK and Lung
Kidney Antibodies	>267 publications with MAK and Kidney
Lymph Node Antibodies	>103 publications with MAK and Lymph Node
Eye Antibodies	>101 publications with MAK and Eye
Intestine Antibodies	>79 publications with MAK and Intestine
Testis Antibodies	>32 publications with MAK and Testis
Esophagus Antibodies	>19 publications with MAK and Esophagus