NME1 Antibody – Mouse Monoclonal

NME1: an enzyme with multiple activities including histidine protein kinase, nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase and 3'-5' exonuclease activities. Plays a major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Involved in cell proliferation, differentiation and development, G protein-coupled receptor endocytosis, cytotoxic T cell and NK cell-mediated cell death, and gene expression. Required for neural development including neural patterning and cell fate determination. During granzyme A (GZMA)-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Three alternatively spliced human proteins have been reported.

Protein type: EC 2.7.4.6; Kinase, other; Tumor suppressor; Nucleotide Metabolism - purine; Kinase, nucleoside diphosphate; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Other group; NDK family

Chromosomal Location of Human Ortholog: 17q21.3

Cellular Component: membrane; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; GTP binding; magnesium ion binding; nucleoside diphosphate kinase activity; deoxyribonuclease activity; ribosomal small subunit binding; ATP binding

Biological Process: GTP biosynthetic process; nervous system development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; UTP biosynthetic process; nucleoside diphosphate phosphorylation; endocytosis; DNA catabolic process; regulation of apoptosis; negative regulation of cell proliferation; CTP biosynthetic process; pyrimidine nucleotide metabolic process; nucleoside triphosphate biosynthetic process; cell differentiation; positive regulation of epithelial cell proliferation; purine nucleotide metabolic process; positive regulation of DNA binding

Disease: Neuroblastoma, Susceptibility To