Flt1, Ed (FZD1) Antibody – Mouse Monoclonal

FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: neuron projection; cell surface; focal adhesion; membrane; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; identical protein binding; Wnt-protein binding; signal transducer activity; Wnt receptor activity; protein homodimerization activity; transmembrane receptor activity; protein heterodimerization activity; frizzled binding; PDZ domain binding; receptor binding

Biological Process: response to drug; G-protein coupled receptor protein signaling pathway; Wnt receptor signaling pathway; cell surface receptor linked signal transduction; epithelial cell differentiation; cell-cell signaling; multicellular organismal development; positive regulation of transcription, DNA-dependent; hard palate development; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription, DNA-dependent; signal transduction; negative regulation of BMP signaling pathway