Synuclein, Alpha, Beta (SPTBN1) Antibody – Mouse Monoclonal

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SPTBN1: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: spectrin; protein complex; cytoplasm; nucleolus; M band; axolemma; cytosol

Molecular Function: calmodulin binding; protein binding; structural constituent of cytoskeleton; protein complex binding; phospholipid binding; ankyrin binding; actin binding

Biological Process: axon guidance; cytokinesis after mitosis; plasma membrane organization and biogenesis; actin filament capping; Golgi to plasma membrane protein transport; common-partner SMAD protein phosphorylation; SMAD protein nuclear translocation