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MMP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6321308

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MMP1, Polyclonal Antibody
Full Product Name
MMP1, ID (MMP1, CLG, Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, 22kD interstitial collagenase, 27kD interstitial collagenase) (Biotin)
Product Gene Name
anti-MMP1 antibody
Product Synonym Names
MMP1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; 22kD interstitial collagenase; 27kD interstitial collagenase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
54,007 Da
OMIM
120353
3D Structure
ModBase 3D Structure for P03956
Immunogen
MMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-349 amino acids from the Central region of human MMP1.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-MMP1 antibody

Antibodies; Matrix Metalloproteinases
Applications Tested/Suitable for anti-MMP1 antibody
Immunofluorescence (IF), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-MMP1 antibody
IF: 1:10-50
ELISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-MMP1 antibody

MMP1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the MMP1 antibody detected the MMP1 protein (arrow).
Rabbit Anti-MMP1 Polyclonal Antibody – Cat# MBS6321308

Immunohistochemistry (IHC) of anti-MMP1 antibody

MMP1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-MMP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6321308

Immunofluorescence (IF) of anti-MMP1 antibody

Confocal immunofluorescent analysis of MMP1 Antibody (Center) with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-MMP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6321308

Product References and Citations for anti-MMP1 antibody

Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010). Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010): Malik, N., et al. J. Neurooncol. (2010). In press: Skorupski, P., et al. Ginekol. Pol. 81(8):594-599(2010). Mossbock, G., et al. Mol. Vis. 16, 1764-1770 (2010).

Other Notes

Small volumes of anti-MMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP1 purchase

MBS6321308 is an antibody targeting MMP1. Also known as MMP1, ID (MMP1, CLG, Interstitial collagenase, Fibroblast collagenase, Matrix metalloproteinase-1, 22kD interstitial collagenase, 27kD interstitial collagenase) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP1. It may not necessarily be applicable to this product.

NCBI GI #
4505215
NCBI GeneID
4312
NCBI Accession #
NP_002412
UniProt Primary Accession #
P03956
UniProt Secondary Accession #
P08156
UniProt Related Accession #
P03956
GenBank Nucleotide #
NM_002421.3
NCBI Official Full Name
interstitial collagenase isoform 1 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 1 (interstitial collagenase)
NCBI Official Symbol
MMP1
NCBI Official Synonym Symbols
CLG; CLGN
UniProt Protein Name
Interstitial collagenase
UniProt Synonym Protein Names
Fibroblast collagenase; Matrix metalloproteinase-1
Protein Family
Interstitial collagenase
UniProt Gene Name
MMP1
UniProt Synonym Gene Names
CLG; MMP-1
UniProt Entry Name
MMP1_HUMAN
NCBI Protein Information
interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1

UniProt Comments for MMP1

MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family.

Protein type: Protease; Secreted, signal peptide; EC 3.4.24.7; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding

Biological Process: positive regulation of protein oligomerization; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; cellular protein metabolic process; viral reproduction; blood coagulation; proteolysis; leukocyte migration

Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP1 antibody

 Reference Product  PubMed Publications
 TIMP1 antibody  >100 publications with MMP1 and TIMP1
 MMP7 antibody  >46 publications with MMP1 and MMP7
 CCL2 antibody  >10 publications with MMP1 and CCL2
 COL2A1 antibody  >7 publications with MMP1 and COL2A1
 TNFSF11 antibody  >7 publications with MMP1 and TNFSF11
 CD44 antibody  >4 publications with MMP1 and CD44
 BSG antibody  >4 publications with MMP1 and BSG
 ACAN antibody  >4 publications with MMP1 and ACAN
 ITGA2 antibody  >3 publications with MMP1 and ITGA2
 IGFBP3 antibody  >2 publications with MMP1 and IGFBP3

Pathways associated with anti-MMP1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram

Diseases associated with anti-MMP1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >231 publications with MMP1 and Neoplasms
 Inflammation Antibodies  >89 publications with MMP1 and Inflammation
 Cardiovascular Diseases Antibodies  >68 publications with MMP1 and Cardiovascular Diseases
 Neoplasm Invasiveness Antibodies  >65 publications with MMP1 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >63 publications with MMP1 and Lung Diseases
 Necrosis Antibodies  >59 publications with MMP1 and Necrosis
 Neoplasm Metastasis Antibodies  >52 publications with MMP1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >48 publications with MMP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >36 publications with MMP1 and Lung Neoplasms
 Heart Diseases Antibodies  >29 publications with MMP1 and Heart Diseases

Organs/Tissues associated with anti-MMP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >111 publications with MMP1 and Blood
 Skin Antibodies  >105 publications with MMP1 and Skin
 Lung Antibodies  >84 publications with MMP1 and Lung
 Vascular Antibodies  >74 publications with MMP1 and Vascular
 Bone Antibodies  >71 publications with MMP1 and Bone
 Connective Tissue Antibodies  >65 publications with MMP1 and Connective Tissue
 Muscle Antibodies  >38 publications with MMP1 and Muscle
 Liver Antibodies  >26 publications with MMP1 and Liver
 Embryonic Tissue Antibodies  >26 publications with MMP1 and Embryonic Tissue
 Eye Antibodies  >24 publications with MMP1 and Eye
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