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MYLK3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6323392

Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYLK3, Polyclonal Antibody
Full Product Name
MYLK3, ID (MYLK3, MLCK, Putative myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase) (MaxLight 550)
Product Gene Name
anti-MYLK3 antibody
Product Synonym Names
MYLK3; MLCK; Putative myosin light chain kinase 3; Cardiac-MyBP-C-associated Ca/CaM kinase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
52,723 Da
OMIM
AJ247087 mRNA
3D Structure
ModBase 3D Structure for Q32MK0
Immunogen
MYLK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 542-570 amino acids from the Central region of human MYLK3.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-MYLK3 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-MYLK3 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-MYLK3 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-MYLK3 antibody

Al-Sadi, R., et al. J. Immunol. 180(8):5653-5661(2008). Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008). Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007).

Other Notes

Small volumes of anti-MYLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYLK3 purchase

MBS6323392 is an antibody targeting MYLK3. Also known as MYLK3, ID (MYLK3, MLCK, Putative myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MYLK3. It may not necessarily be applicable to this product.

NCBI GI #
146219832
NCBI GeneID
91807
NCBI Accession #
NP_872299.2
UniProt Primary Accession #
Q32MK0
UniProt Secondary Accession #
Q32MK1; Q96DV1; B5BUL9; B7Z5U8
UniProt Related Accession #
Q32MK0
GenBank Nucleotide #
NM_182493.2
NCBI Official Full Name
myosin light chain kinase 3
NCBI Official Synonym Full Names
myosin light chain kinase 3
NCBI Official Symbol
MYLK3
NCBI Official Synonym Symbols
MLCK; MLCK2; caMLCK
UniProt Protein Name
Myosin light chain kinase 3
UniProt Synonym Protein Names
Cardiac-MyBP-C-associated Ca/CaM kinase; Cardiac-MLCK
Protein Family
Myosin light chain kinase
UniProt Gene Name
MYLK3
UniProt Synonym Gene Names
MLCK; Cardiac-MLCK
NCBI Protein Information
myosin light chain kinase 3; MLC kinase; cardiac-MLCK; putative myosin light chain kinase 3; cardiac-MyBP-C associated Ca/CaM kinase; cardiac-MyBP-C-associated Ca/CaM kinase

UniProt Comments for MYLK3

caMLCK: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: CAMK group; EC 2.7.11.18; Kinase, protein; MLCK family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16q11.2

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; intracellular

Molecular Function: ATP binding; calmodulin-dependent protein kinase activity; myosin light chain kinase activity

Biological Process: cardiac myofibril assembly; cellular response to interleukin-1; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid phosphorylation; regulation of vascular permeability during acute inflammatory response; sarcomere organization; sarcomerogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYLK3 antibody

 Reference Product  PubMed Publications
 CALM1 antibody  >1 publications with MYLK3 and CALM1

Pathways associated with anti-MYLK3 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram

Diseases associated with anti-MYLK3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2 publications with MYLK3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with MYLK3 and Disease Models, Animal
 Hypertrophy Antibodies  >1 publications with MYLK3 and Hypertrophy
 Cardiomegaly Antibodies  >1 publications with MYLK3 and Cardiomegaly

Organs/Tissues associated with anti-MYLK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3 publications with MYLK3 and Heart
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