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MYT1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6323593

MBS6323593 is an antibody targeting MYT1. Also known as MYT1, CT (Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase, Myt1 kinase, PKMYT1, MYT1,) (PE). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYT1, Polyclonal Antibody
Full Product Name
MYT1, CT (Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase, Myt1 kinase, PKMYT1, MYT1,) (PE)
Product Gene Name
anti-MYT1 antibody
Product Synonym Gene Name
PKMYT1
Product Synonym Names
Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; PKMYT1; MYT1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Peptide Immunoaffinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
54,521 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (3022792..3030540, complement). Location: 16p13.3
OMIM
602474
3D Structure
ModBase 3D Structure for Q99640
Immunogen
MYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding T495 of human MYT1.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-MYT1 antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-MYT1 antibody
FLISA, Western Blot (WB)
Application Notes for anti-MYT1 antibody
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-MYT1 antibody

Dai, X., et al., J. Invest. Dermatol. 122(6):1356-1364 (2004). Nakajima, H., et al., J. Biol. Chem. 278(28):25277-25280 (2003). Passer, B.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100(5):2284-2289 (2003). Okumura, E., et al., Nat. Cell Biol. 4(2):111-116 (2002). Booher, R.N., et al., J. Biol. Chem. 272(35):22300-22306 (1997).

Other Notes

Small volumes of anti-MYT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYT1. It may not necessarily be applicable to this product.

NCBI GI #
33383241
NCBI GeneID
9088
NCBI Accession #
NP_004194.3
UniProt Primary Accession #
Q99640
UniProt Secondary Accession #
O14731; Q7LE24; Q8TCM9; D3DUA4; F8W164
UniProt Related Accession #
Q99640
GenBank Nucleotide #
NM_004203.4
NCBI Official Full Name
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1
NCBI Official Synonym Full Names
protein kinase, membrane associated tyrosine/threonine 1
NCBI Official Symbol
PKMYT1
NCBI Official Synonym Symbols
MYT1
UniProt Protein Name
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
UniProt Synonym Protein Names
Myt1 kinase
Protein Family
Myelin transcription factor
UniProt Gene Name
PKMYT1
UniProt Synonym Gene Names
MYT1
UniProt Entry Name
PMYT1_HUMAN
NCBI Protein Information
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; myt1 kinase

NCBI Summary for MYT1

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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UniProt Comments for MYT1

Myt1: a dual specificity protein kinase of the WEE family. Preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Alternative splice-variant isoforms have been reported.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); Other group; WEE family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; kinase activity; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of cell cycle; regulation of mitosis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation; G1/S transition of mitotic cell cycle
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Research Articles on MYT1

1. Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYT1 antibody

 Reference Product  PubMed Publications
 CCNB1 antibody  >9 publications with MYT1 and CCNB1
 CDK1 antibody  >5 publications with MYT1 and CDK1
 PLK1 antibody  >2 publications with MYT1 and PLK1
 PIN1 antibody  >1 publications with MYT1 and PIN1

Pathways associated with anti-MYT1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin A/B1 Associated Events During G2/M Transition Pathway antibodies  Cyclin A/B1 Associated Events During G2/M Transition Pathway Diagram
 Cyclin E Associated Events During G1/S Transition Pathway antibodies  Cyclin E Associated Events During G1/S Transition Pathway Diagram
 G1/S Transition Pathway antibodies  G1/S Transition Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G1-G1/S Phases Pathway antibodies  Mitotic G1-G1/S Phases Pathway Diagram

Diseases associated with anti-MYT1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with MYT1 and Neoplasms
 Glioma Antibodies  >1 publications with MYT1 and Glioma
 Kidney Neoplasms Antibodies  >1 publications with MYT1 and Kidney Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with MYT1 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with MYT1 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with MYT1 and Breast Neoplasms

Organs/Tissues associated with anti-MYT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with MYT1 and Kidney
 Liver Antibodies  >1 publications with MYT1 and Liver
 Blood Antibodies  >1 publications with MYT1 and Blood
 Brain Antibodies  >1 publications with MYT1 and Brain
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