Rabbit Anti-NDRG4 Polyclonal Antibody – Cat# MBS6324286

NDRG4 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the NDRG4 antibody detected the NDRG4 protein (arrow).

NDRG4 Antibody – Rabbit Polyclonal

Name: NDRG4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6324286
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6324286

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NDRG4, Polyclonal Antibody

Full Product Name

NDRG4, ID (NDRG4, BDM1, KIAA1180, Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8) (PE)

Product Gene Name

anti-NDRG4 antibody

Product Synonym Names

NDRG4; BDM1; KIAA1180; Protein NDRG4; Brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; Vascular smooth muscle cell-associated protein 8

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

38,459 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (58497549..58547523). Location: 16q21-q22.1

OMIM

614463

3D Structure

ModBase 3D Structure for Q9ULP0

Immunogen

NDRG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human NDRG4.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-NDRG4 antibody

Antibodies; KIAA; orf

Applications Tested/Suitable for anti-NDRG4 antibody

Western Blot (WB), FLISA

Application Notes for anti-NDRG4 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NDRG4 antibody

Rose, J. Phd, et al. Mol. Med. (2010). In press: Holm, H., et al. Nat. Genet. 42(2):117-122(2010). Schilling, S.H., et al. J. Biol. Chem. 284(37):25160-25169(2009). Melotte, V., et al. J. Natl. Cancer Inst. 101(13):916-927(2009). Pfeufer, A., et al. Nat. Genet. 41(4):407-414(2009).

Other Notes

Small volumes of anti-NDRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDRG4 purchase

MBS6324286 is an antibody targeting NDRG4. Also known as NDRG4, ID (NDRG4, BDM1, KIAA1180, Protein NDRG4, Brain development-related molecule 1, N-myc downstream-regulated gene 4 protein, Vascular smooth muscle cell-associated protein 8) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NDRG4. It may not necessarily be applicable to this product.

NCBI GI #

194440722

NCBI GeneID

65009

NCBI Accession #

NP_001123959.1

NCBI Related Accession #

NP_065198.1

UniProt Primary Accession #

Q9ULP0

UniProt Secondary Accession #

Q6ZNE7; Q6ZTI7; Q96PL9; Q9GZM1; Q9GZN3; Q9GZX0; B3KNU2; B4DK66; B4DSW5; H7C600

UniProt Related Accession #

Q9ULP0

GenBank Nucleotide #

NM_001130487.1

NCBI Official Full Name

protein NDRG4 isoform 2

NCBI Official Synonym Full Names

NDRG family member 4

NCBI Official Symbol

NDRG4

NCBI Official Synonym Symbols

BDM1; SMAP8; SMAP-8

UniProt Protein Name

Protein NDRG4

UniProt Synonym Protein Names

Brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; Vascular smooth muscle cell-associated protein 8

Protein Family

Protein

UniProt Gene Name

NDRG4

UniProt Synonym Gene Names

BDM1; KIAA1180; SMAP-8

UniProt Entry Name

NDRG4_HUMAN

NCBI Protein Information

protein NDRG4; smooth muscle-associated protein 8; brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; vascular smooth muscle cell-associated protein 8

NCBI Summary for NDRG4

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

UniProt Comments for NDRG4

NDRG4: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Expressed predominantly in brain and heart. In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. Belongs to the NDRG family. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: endoplasmic reticulum membrane; mitochondrion; basolateral plasma membrane; cytoplasm; cytosol

Biological Process: negative regulation of smooth muscle cell proliferation; response to stress; embryonic heart tube development; cardiac muscle cell proliferation; heart looping; negative regulation of smooth muscle cell migration; cell growth; cell differentiation

Research Articles on NDRG4

1. NDRG4 is involved in modulating cell proliferation, invasion, migration and angiogenesis in meningioma, and may play a valuable role as a molecular target in its treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-NDRG4 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>3 publications with NDRG4 and Carcinoma
Glioma Antibodies	>3 publications with NDRG4 and Glioma
Prostatic Neoplasms Antibodies	>2 publications with NDRG4 and Prostatic Neoplasms
Breast Neoplasms Antibodies	>2 publications with NDRG4 and Breast Neoplasms
Disease Models, Animal Antibodies	>1 publications with NDRG4 and Disease Models, Animal
Learning Disorders Antibodies	>1 publications with NDRG4 and Learning Disorders
Liver Neoplasms Antibodies	>1 publications with NDRG4 and Liver Neoplasms
Drug Toxicity Antibodies	>1 publications with NDRG4 and Drug Toxicity
Atherosclerosis Antibodies	>1 publications with NDRG4 and Atherosclerosis
Liver Diseases Antibodies	>1 publications with NDRG4 and Liver Diseases

Organs/Tissues associated with anti-NDRG4 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>23 publications with NDRG4 and Muscle
Nerve Antibodies	>22 publications with NDRG4 and Nerve
Brain Antibodies	>16 publications with NDRG4 and Brain
Heart Antibodies	>9 publications with NDRG4 and Heart
Embryonic Tissue Antibodies	>5 publications with NDRG4 and Embryonic Tissue
Prostate Antibodies	>3 publications with NDRG4 and Prostate
Pancreas Antibodies	>2 publications with NDRG4 and Pancreas
Testis Antibodies	>2 publications with NDRG4 and Testis
Intestine Antibodies	>1 publications with NDRG4 and Intestine
Lymph Node Antibodies	>1 publications with NDRG4 and Lymph Node