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NXPH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6327406

NXPH1 is a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins… More details

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Product Overview

Online Datasheet in PDF
Product Name
NXPH1, Polyclonal Antibody
Full Product Name
NXPH1, NT (NXPH1, NPH1, Neurexophilin-1) (FITC)
Product Gene Name
anti-NXPH1 antibody
Product Synonym Names
NXPH1; NPH1; Neurexophilin-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
31,082 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (8473585..8792593). Location: 7p22
OMIM
604639
3D Structure
ModBase 3D Structure for P58417
Immunogen
NXPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63~93 amino acids from the N-terminal region of human NXPH1.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-NXPH1 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-NXPH1 antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-NXPH1 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-NXPH1 antibody

NXPH1 Antibody (N-term) western blot analysis in mouse cerebellum,brain tissue lysates (35ug/lane).This demonstrates the NXPH1 antibody detected the NXPH1 protein (arrow).
Rabbit Anti-NXPH1 Polyclonal Antibody – Cat# MBS6327406

Immunohistochemistry (IHC) of anti-NXPH1 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with NXPH1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-NXPH1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6327406

Flow Cytometry (FC/FACS) of anti-NXPH1 antibody

NXPH1 Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-NXPH1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6327406

Product References and Citations for anti-NXPH1 antibody

Xu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(5):2136-2140(2010). Shen, L., et al. Neuroimage (2010). In press: Van den Oord, E.J., et al. Arch. Gen. Psychiatry 65(9):1062-1071(2008). Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008). Ohira, M., et al. Cancer Lett. 197 (1-2), 63-68 (2003).

Other Notes

Small volumes of anti-NXPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NXPH1 purchase

MBS6327406 is an antibody targeting NXPH1. Also known as NXPH1, NT (NXPH1, NPH1, Neurexophilin-1) (FITC). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NXPH1. It may not necessarily be applicable to this product.

NCBI GI #
23097338
NCBI GeneID
30010
NCBI Accession #
NP_689958.1
UniProt Primary Accession #
P58417
UniProt Secondary Accession #
Q8NB31
UniProt Related Accession #
P58417
GenBank Nucleotide #
NM_152745.2
NCBI Official Full Name
neurexophilin-1
NCBI Official Synonym Full Names
neurexophilin 1
NCBI Official Symbol
NXPH1
NCBI Official Synonym Symbols
NPH1; Nbla00697
UniProt Protein Name
Neurexophilin-1
Protein Family
Neurexophilin
UniProt Gene Name
NXPH1
UniProt Synonym Gene Names
NPH1
UniProt Entry Name
NXPH1_HUMAN
NCBI Protein Information
neurexophilin-1

NCBI Summary for NXPH1

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]
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UniProt Comments for NXPH1

NXPH1: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential). Belongs to the neurexophilin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: extracellular region

Molecular Function: receptor binding
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Research Articles on NXPH1

1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NXPH1 antibody

 Reference Product  PubMed Publications
 NRXN1 antibody  >1 publications with NXPH1 and NRXN1

Diseases associated with anti-NXPH1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with NXPH1 and Nervous System Diseases
 Neoplasms Antibodies  >3 publications with NXPH1 and Neoplasms
 Breast Neoplasms Antibodies  >1 publications with NXPH1 and Breast Neoplasms
 Alzheimer Disease Antibodies  >1 publications with NXPH1 and Alzheimer Disease
 Seizures Antibodies  >1 publications with NXPH1 and Seizures
 Cognition Disorders Antibodies  >1 publications with NXPH1 and Cognition Disorders

Organs/Tissues associated with anti-NXPH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with NXPH1 and Brain
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