Cd41a Antibody – Mouse Monoclonal

The CD41 molecule is the integrin alphaIIb also known as platelet GPIIb. CD41 non-covalently associates with betaIII integrin (GPIIIa, CD61) and is expressed by megakaryocytes and platelets. The CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin and mediates platelets aggregation. This antibody blocks platelet aggregation. CD41 completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. This antibody is useful in the morphological and physiological studies of platelets and megakaryocytes. The GPIIb/IIIa may be absent or strongly reduced in Glanzmann's thrombasthenia (GT).

Small volumes of anti-CD41a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS632820 is an antibody targeting CD41a. Reactive in Human. Host: Mouse.