Mouse Anti-OPRK1 Monoclonal Antibody – Cat# MBS632940

Immunohistochemistry analysis of KOR in immersion fixed paraffin-embedded sections of human brainstem (medulla) using MBS632940 (15ug/ml) overnight at 4°C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval. Tissue was stained with anti-mouse HRP-DAB (brown) and counterstained with hematoxylin (blue).

Opioid Receptor, Kappa (OPRK1) Antibody – Mouse Monoclonal

Name: OPRK1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS632940
Price: 1030 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS632940

Kappa Opioid Receptor (KOR) is a 45kD 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis,… More details

$1030 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Opioid Receptor, kappa (OPRK1), Monoclonal Antibody

Full Product Name

Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK)

Product Gene Name

anti-OPRK1 antibody

Product Synonym Names

Anti -Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

7H182

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human KOR. Detects human KOR transfectants but not irrelevant transfectants. Species Sequence Homology: mouse and rat, 94%

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

42,645 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (54138276..54164194, complement). Location: 8q11.2

OMIM

165196

3D Structure

ModBase 3D Structure for P41145

Immunogen

NS0 cells transfected with human Opioid Receptor, kappa (KOR) (NP_000903).

Product Categories/Family for anti-OPRK1 antibody

Antibodies; Abs to Opioid Receptors; Agonists

Applications Tested/Suitable for anti-OPRK1 antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-OPRK1 antibody

Dilution: Immunohistochemistry (Paraffin): 15ug/ml detects human KOR in paraffin-embedded normal human medulla tissue sections.

Other Notes

Small volumes of anti-OPRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OPRK1 purchase

MBS632940 is an antibody targeting OPRK1. Also known as Opioid Receptor, kappa (OPRK1, Opioid Receptor, kappa 1, Kappa-type Opioid Receptor, KOR, KOR-1, OPRK). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for OPRK1. It may not necessarily be applicable to this product.

NCBI GI #

71533992

NCBI GeneID

4986

UniProt Primary Accession #

P41145

UniProt Secondary Accession #

Q499G4

UniProt Related Accession #

P41145; Q8IWP3

NCBI Official Full Name

Opioid receptor, kappa 1

NCBI Official Synonym Full Names

opioid receptor, kappa 1

NCBI Official Symbol

OPRK1

NCBI Official Synonym Symbols

KOR; OPRK

UniProt Protein Name

Kappa-type opioid receptor

Protein Family

Kappa-type opioid receptor

UniProt Gene Name

OPRK1

UniProt Synonym Gene Names

OPRK

UniProt Entry Name

OPRK_HUMAN

NCBI Protein Information

kappa-type opioid receptor; KOR-1; K-OR-1; OTTHUMP00000226313; OTTHUMP00000226316; kappa opioid receptor; Opiate receptor, kappa-1

UniProt Comments for OPRK1

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; locomotory behavior; regulation of saliva secretion; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain; defense response to virus

Research Articles on OPRK1

1. because of its stronger binding for hKOPR, GEC1 is able to be recruited by hKOPR sufficiently without membrane association via its C-terminal modification; however, du GABARAP appears to require C-terminal modifications to enhance KOPR expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OPRK1 antibody

Reference Product	PubMed Publications
OPRD1 antibody	>12 publications with OPRK1 and OPRD1

Pathways associated with anti-OPRK1 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-OPRK1 antibody

Disease Name	Pubmed Publications
Pain Antibodies	>6 publications with OPRK1 and Pain
Neoplasms Antibodies	>3 publications with OPRK1 and Neoplasms
Prostatic Neoplasms Antibodies	>2 publications with OPRK1 and Prostatic Neoplasms
Anxiety Disorders Antibodies	>1 publications with OPRK1 and Anxiety Disorders

Organs/Tissues associated with anti-OPRK1 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>2 publications with OPRK1 and Prostate
Brain Antibodies	>2 publications with OPRK1 and Brain