Rabbit Anti-OSBPL1A Polyclonal Antibody – Cat# MBS6329712

OSBPL1A Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the OSBPL1A antibody detected the OSBPL1A protein (arrow).

OSBPL1A Antibody – Rabbit Polyclonal

Name: OSBPL1A Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6329712
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6329712

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OSBPL1A, Polyclonal Antibody

Full Product Name

OSBPL1A, CT (OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B, Oxysterol-binding protein-related protein 1) (PE)

Product Gene Name

anti-OSBPL1A antibody

Product Synonym Names

OSBPL1A; ORP1; OSBP8; OSBPL1; OSBPL1B; Oxysterol-binding protein-related protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

606730

3D Structure

ModBase 3D Structure for Q9BXW6

Immunogen

OSBPL1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 734-763 amino acids from the C-terminal region of human OSBPL1A.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-OSBPL1A antibody

Antibodies; Binding Proteins

Applications Tested/Suitable for anti-OSBPL1A antibody

Western Blot (WB), FLISA

Application Notes for anti-OSBPL1A antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-OSBPL1A antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010): Rocha, N., et al. J. Cell Biol. 185(7):1209-1225(2009). Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008): Bjornsson, H.T., et al. Genome Res. 18(5):771-779(2008).

Other Notes

Small volumes of anti-OSBPL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSBPL1A purchase

MBS6329712 is an antibody targeting OSBPL1A. Also known as OSBPL1A, CT (OSBPL1A, ORP1, OSBP8, OSBPL1, OSBPL1B, Oxysterol-binding protein-related protein 1) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OSBPL1A. It may not necessarily be applicable to this product.

NCBI GI #

19718741

NCBI GeneID

114876

NCBI Accession #

NP_542164.2

NCBI Related Accession #

NP_060500.3

UniProt Primary Accession #

Q9BXW6

UniProt Related Accession #

Q9BXW6

GenBank Nucleotide #

NP_542164.2

NCBI Official Full Name

oxysterol-binding protein-related protein 1 isoform 2

NCBI Official Synonym Full Names

oxysterol binding protein like 1A

NCBI Official Symbol

OSBPL1A

NCBI Official Synonym Symbols

ORP1; ORP-1; OSBPL1B

UniProt Protein Name

Oxysterol-binding protein-related protein 1

Protein Family

Oxysterol-binding protein-related protein

UniProt Gene Name

OSBPL1A

UniProt Synonym Gene Names

ORP1; OSBP8; OSBPL1; OSBPL1B; ORP-1; OSBP-related protein 1

UniProt Entry Name

OSBL1_HUMAN

NCBI Protein Information

oxysterol-binding protein-related protein 1

UniProt Comments for OSBPL1A

OSBPL1A: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Belongs to the OSBP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.1

Cellular Component: nucleoplasm; lysosomal membrane; cytoplasm; late endosome; intracellular; nucleus

Molecular Function: protein binding; cholesterol binding; phospholipid binding

Biological Process: vesicle-mediated transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; lipid transport

Research Articles on OSBPL1A

1. ORP1 is a unique sensor of lysosomal phosphatidylinosito-bisphosphates, and that PI(4,5)P2/PI(3,4)P2 allosterically regulates cholesterol transport by ORP1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.