Rabbit Anti-OTOL1 Polyclonal Antibody – Cat# MBS6329821

Western Blot analysis in NCI-H292 cell line lysates (35ug/lane) usingMBS6005685. This demonstrates that MBS6005685 detected the OTOL1 protein (arrow).

OTOL1 Antibody – Rabbit Polyclonal

Name: OTOL1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6329821
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6329821

MaxLight750 is a new Near IR stable dye conjugate comparable to DyLight750, Alexa Fluor700 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (759nm); Emission (780nm); Extinction Coefficient 240,000. More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OTOL1, Polyclonal Antibody

Full Product Name

OTOL1, NT (OTOL1, Otolin-1) (MaxLight 750)

Product Gene Name

anti-OTOL1 antibody

Product Synonym Names

OTOL1; Otolin-1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A and Peptide Affinity Chromatography.

Specificity

Recognizes human OTOL1.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

49,422 Da

3D Structure

ModBase 3D Structure for A6NHN0

Immunogen

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 11-39 in the N-terminal region of human OTOL1.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-OTOL1 antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-OTOL1 antibody

Western Blot (WB), FLISA

Application Notes for anti-OTOL1 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-OTOL1 antibody

1. Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008). 2. Ghai, R., et al. Immunobiology 212 (4-5), 253-266 (2007). 3. Murayama, E., et al. Mech. Dev. 122(6):791-803(2005).

Other Notes

Small volumes of anti-OTOL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OTOL1 purchase

MBS6329821 is an antibody targeting OTOL1. Also known as OTOL1, NT (OTOL1, Otolin-1) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OTOL1. It may not necessarily be applicable to this product.

NCBI GI #

122937273

NCBI GeneID

131149

NCBI Accession #

NP_001073909.1

UniProt Primary Accession #

A6NHN0

UniProt Related Accession #

A6NHN0

GenBank Nucleotide #

NM_001080440.1

NCBI Official Full Name

otolin-1

NCBI Official Synonym Full Names

otolin 1

NCBI Official Symbol

OTOL1

NCBI Official Synonym Symbols

C1QTNF15; C1QTNF16

UniProt Protein Name

Otolin-1

Protein Family

Otolin

UniProt Gene Name

OTOL1

NCBI Protein Information

otolin-1

NCBI Summary for OTOL1

This gene encodes a secreted glycoprotein with a C-terminal complement Cq1-like globular domain that belongs to the C1q/tumor necrosis factor-related protein (CTRP) family. The encoded protein is expressed in the inner ear and forms a multimeric complex called the otoconia, together with cerebellin-1 and otoconin-90, as part of the otoconial membrane. It contains extensive posttranslational modifications including hydroxylated prolines and glycosylated lysines. Naturally occurring mutations in this gene are associated with abnormal otoconia formation and balance deficits resulting from vestibular dysfunction. [provided by RefSeq, Jul 2017]

UniProt Comments for OTOL1

Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics.

Research Articles on OTOL1

1. An expression and purification procedure for the C1q-like domain of human otolin-1 was developed. It forms stable trimers in solution in the presence of calcium ions. C1q-like domains were stabilized by the calcium ions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OTOL1 antibody

Reference Product	PubMed Publications
C14orf145 antibody	>1 publications with OTOL1 and C14orf145