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OTU7B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6329870

OTU7B has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin. Negative regulator of nuclear factor NF-kappa-B. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
OTU7B, Polyclonal Antibody
Full Product Name
OTU7B, CT (OTUD7B, ZA20D1, OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne) (FITC)
Product Gene Name
anti-OTU7B antibody
Product Synonym Gene Name
OTUD7B
Product Synonym Names
OTUD7B; ZA20D1; OTU domain-containing protein 7B; Cellular zinc finger anti-NF-kappa-B protein; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
88,947 Da
OMIM
611748
3D Structure
ModBase 3D Structure for Q6GQQ9
Immunogen
OTU7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-784 amino acids from the C-terminal region of human OTU7B.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-OTU7B antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-OTU7B antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-OTU7B antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-OTU7B antibody

OTU7B Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the OTU7B antibody detected the OTU7B protein (arrow).
Rabbit Anti-OTU7B Polyclonal Antibody – Cat# MBS6329870

Immunohistochemistry (IHC) of anti-OTU7B antibody

OTU7B Antibody (C-term) (AP14281b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of OTU7B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-OTU7B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6329870

Product References and Citations for anti-OTU7B antibody

Bremm, A., et al. Nat. Struct. Mol. Biol. 17(8):939-947(2010). Jin, Z., et al. Cell 137(4):721-735(2009). Enesa, K., et al. J. Biol. Chem. 283(27):18582-18590(2008). Bohgaki, M., et al. Biochim. Biophys. Acta 1783(5):826-837(2008). Enesa, K., et al. J. Biol. Chem. 283(11):7036-7045(2008).

Other Notes

Small volumes of anti-OTU7B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OTU7B purchase

MBS6329870 is an antibody targeting OTU7B. Also known as OTU7B, CT (OTUD7B, ZA20D1, OTU domain-containing protein 7B, Cellular zinc finger anti-NF-kappa-B protein, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OTU7B. It may not necessarily be applicable to this product.

NCBI GI #
118026942
NCBI GeneID
56957
NCBI Accession #
NP_064590.2
UniProt Primary Accession #
Q6GQQ9
UniProt Secondary Accession #
Q5SZ60; Q8WWA7; Q9NQ53; Q9UFF4; B7Z643; D3DUZ8
UniProt Related Accession #
Q6GQQ9
GenBank Nucleotide #
NM_020205.3
NCBI Official Full Name
OTU domain-containing protein 7B
NCBI Official Synonym Full Names
OTU deubiquitinase 7B
NCBI Official Symbol
OTUD7B
NCBI Official Synonym Symbols
ZA20D1; CEZANNE
UniProt Protein Name
OTU domain-containing protein 7B
UniProt Synonym Protein Names
Cellular zinc finger anti-NF-kappa-B protein; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne
UniProt Gene Name
OTUD7B
UniProt Synonym Gene Names
ZA20D1
UniProt Entry Name
OTU7B_HUMAN
NCBI Protein Information
OTU domain-containing protein 7B; OTU domain containing 7B; zinc finger protein Cezanne; zinc finger, A20 domain containing 1; cellular zinc finger anti-NF-kappaB Cezanne; zinc finger A20 domain-containing protein 1; cellular zinc finger anti-NF-kappa-B p

UniProt Comments for OTU7B

Cezanne: cellular zinc finger anti-NF-kappaB, a negative regulator of NF-kappaB. A novel deubiquitinating enzyme that belongs to the ovarian tumor protein (OTU) superfamily.

Protein type: EC 3.4.19.12; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-specific protease activity; cysteine-type peptidase activity

Biological Process: mucosal immune response; negative regulation of interleukin-8 production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; proteolysis
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Research Articles on OTU7B

1. Inflammatory responses to ischemia are controlled by a balance between TRAF6 ubiquitination and deubiquitination, and Cezanne is a key regulator of this process.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OTU7B antibody

 Reference Product  PubMed Publications
 TRAF6 antibody  >3 publications with OTU7B and TRAF6
 MTMR11 antibody  >2 publications with OTU7B and MTMR11
 SF3B4 antibody  >1 publications with OTU7B and SF3B4

Diseases associated with anti-OTU7B antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with OTU7B and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with OTU7B and Neoplasms, Experimental
 Necrosis Antibodies  >3 publications with OTU7B and Necrosis
 Hyperplasia Antibodies  >2 publications with OTU7B and Hyperplasia
 Disease Models, Animal Antibodies  >1 publications with OTU7B and Disease Models, Animal
 Liver Neoplasms, Experimental Antibodies  >1 publications with OTU7B and Liver Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with OTU7B and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with OTU7B and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with OTU7B and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >1 publications with OTU7B and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-OTU7B antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >3 publications with OTU7B and Heart
 Kidney Antibodies  >3 publications with OTU7B and Kidney
 Intestine Antibodies  >2 publications with OTU7B and Intestine
 Lung Antibodies  >2 publications with OTU7B and Lung
 Bone Antibodies  >1 publications with OTU7B and Bone
 Muscle Antibodies  >1 publications with OTU7B and Muscle
 Skin Antibodies  >1 publications with OTU7B and Skin
 Liver Antibodies  >1 publications with OTU7B and Liver
 Mouth Antibodies  >1 publications with OTU7B and Mouth
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