Granulocytes (CD15) Antibody – Mouse Monoclonal

This is a hematopoietic differentiation antigen (also named SSEA-1, stage-speci c embryonic antigen) expressed on most terminally differentiated myeloid cells including granulocytes, monocytes, eosinophils, mast cells, macrophages and Langerhans cells.On progenitor cells CD15 is coexpressed by 0.25 to 1% of bone marrow CD34+ cells.(2) In the peripheral blood growth factor mobilized CD34+ cells expressed CD15

CD15 plays a role in mediating phagocytosis, bactericidal activity, and chemotaxis. It is present on >95% of granulocytes including neutrophils and eosinophils and to a lesser degree on monocytes. In addition, CD15 is expressed in Reed-Sternberg cells and some epithelial cells. CD15 antibody is very useful in the identification of Hodgkin's disease. CD15 is occasionally expressed in large cell lymphomas of both B and T phenotypes which otherwise have a quite distinct histological appearance.
This antibody has been assigned to the CD15 cluster of differentiation at the Vth International Workshop on Human Leukocyte Differentiation Antigens in Boston (1993).

Small volumes of anti-CD15, Granulocytes antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS633035 is an antibody targeting CD15, Granulocytes. Also known as CD15, Granulocytes (Lewis x, Le x, Hematopoietic Differentiation Antigen, SSEA-1, Stage-specic Embryonic Antigen, X Hapten, 3-fucosyl-N-acetyllactosamine, 3-FAL) (Biotin). Reactive in Human. Host: Mouse.